中国医学工程2025，Vol.33Issue(5)：40-45,6.DOI:10.19338/j.issn.1672-2019.2025.05.009
一氧化碳中毒严重程度相关因素分析
Factors related to severity of acute carbon monoxide poisoning patients
摘要
Abstract
[Objective]To investigate the correlation between early blood routine,renal function,hepatic function,coagulation function,cardiac enzymes,arterial blood lactic acid(LA),C-reactive protein(CRP),and head CT and the severity of the disease in patients with acute carbon monoxide poisoning(ACOP).[Methods]ACOP patients admitted to Changde Hospital Affiliated to Xiangya School of Medicine from January 1,2020 to June 1,2023 and diagnosed according to the"2022 Expert Consensus on Diagnosis and Treatment of Acute Carbon Monoxide Poisoning"were selected and divided into a mild poisoning group(n=111)and a moderately-severe poisoning group(n=43).Relevant data such as blood routine,renal function,hepatic function,coagulation function,cardiac myokine enzyme,LA,CRP and head CT samples were collected from patients at the time of admission.Logistic risk regression analysis was used to screen out the factors influencing the severity of ACOP,and the predictive value of the related indexes on the severity of ACOP was analyzed through the reciever operating characteristic curve.[Results]Multifactorial logistic regression analysis showed that AST(O^R:1.01,95%CI:1.00-1.02),prothrombin time(PT)(O^R:0.45,95%CI:0.22-0.86),fibrinogen(FIB)(O^R:1.34,95%CI:1.04-1.77),thrombin time(TT)(O^R:0.71,95%CI:0.5-0.97),LA(O^R:1.23,95%CI:1.02-1.50),CRP(O^R:1.03,95%CI:1.01-1.05),and head CT abnormality(O^R:8.86,95%CI:3.03-29.08)were independent risk factors for the severity of disease in ACOP patients(P<0.05).The area under the curve of the model in predicting the severity of disease in ACOP patients was 0.884(95%CI:0.818-0.950,P<0.001),with a sensitivity of 0.837 and a specificity of 0.883,indicating that the model had a good differentiation from the actual situation in predicting the severity of disease in ACOP patients.[Conclusion]AST,PT,FIB,TT,LA,CRP,and head CT abnormalities are independent risk factors for the severity of ACOP,and clinical interventions can be formulated early according to the above indicators.关键词
急性一氧化碳中毒/凝血功能/动脉血乳酸/C反应蛋白/头部CTKey words
acute carbon monoxide poisoning/coagulation function/arterial blood lactic acid/C-reactive protein/head CT分类
医药卫生引用本文复制引用
申佩,钟怡..一氧化碳中毒严重程度相关因素分析[J].中国医学工程,2025,33(5):40-45,6.基金项目
湖南省常德市科技局技术创新引导项目(CDKJJ20220615) （CDKJJ20220615）
