中国药业2025，Vol.34Issue(11)：54-60,7.DOI:10.3969/j.issn.1006-4931.2025.11.012
基于指纹图谱和网络药理学的通脉乐口服液质量标志物预测
Prediction of Quality Markers of Tongmaile Oral Liquid Based on the Fingerprints and Network Pharmacology
摘要
Abstract
Objective To predict the quality markers(Q-markers)of Tongmaile Oral Liquid by the fingerprint and network pharmacology.Methods High-performance liquid chromatography(HPLC)method was used to establish the fingerprints of 10 batches of Tongmaile Oral Liquid.The Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine(Version 2012)was used for similarity evaluation and component identification.The ″component-target-pathway″ network of common peaks in the fingerprints was constructed through network pharmacology,and the potential Q-markers of Tongmaile Oral Liquid were predicted.Results The fingerprints of Tongmaile Oral Liquid were established,with fourteen peaks confirmed and three peaks identified,which were calycosin-7-O-glucoside,lobetyolin and formononetin.In the three known components in the fingerprint analyzed by the network pharmacology,65 core targets and 20 key signaling pathways were screened,which might exert their effects through targets such as SRC,PIK3R1,MAPK1,Akt1,GRB2,etc.Conclusion Calycosin-7-O-glucoside,lobetyolin and formononetin can be taken as Q-markers of Tongmaile Oral Liquid to invigorate Qi and blood,nourish Yin and promote fluid effects,which can provide a reference for the establishment of the quality standard for Tongmaile Oral Liquid.关键词
通脉乐口服液/质量标志物/高效液相色谱法/指纹图谱/网络药理学Key words
Tongmaile Oral Liquid/quality marker/HPLC/fingerprint/network pharmacology分类
医药卫生引用本文复制引用
李秋萍,李倩,谭柳萍,韦忠文,张洪平,陆世银..基于指纹图谱和网络药理学的通脉乐口服液质量标志物预测[J].中国药业,2025,34(11):54-60,7.基金项目
广西壮族自治区中医药管理局自筹经费科研课题[GXZYB20240547,GZZC2020421] （）
广西中医药大学校级科研项目[2020MS056]. （）
