中国兽药杂志2025，Vol.59Issue(5)：61-68,8.DOI:10.11751/ISSN.1002-1280.2025.5.09
狂犬病mRNA疫苗的研究进展
Research Progress of mRNA Vaccine for Rabies
焦文杰 1印春生 1王诗妍 1张石豪 1倪静颖 1韩凤烨 1赵丹楠1
作者信息
- 1. 中国兽医药品监察所(农业农村部兽药评审中心),北京 100081
- 折叠
摘要
Abstract
Rabies,as an ancient and fatal zoonotic disease,still poses a serious threat to global public health safety.Vaccination is the core strategy to interrupt the transmission of the virus,and mRNA vaccines provide a new direction for the prevention and control of rabies due to their rapid development potential,highly efficient immunogenicity,and flexible production process.Focusing on the progress of rabies mRNA vaccine research and development,the molecular design principle and delivery system optimization strategy of mRNA vaccine were systematically explained;The immunogenicity characteristics of the rabies mRNA vaccine,including its potential advantages in virus-neutralizing activity and long-term immune memory,had been characterized through the integration of data from preclinical studies and Phase Ⅰ clinical trials.The challenges faced by rabies mRNA vaccines were examined in terms of stability,long-term safety,and inter-individual variability in immunogenicity,with corresponding recommendations being provided.It is believed that rabies mRNA vaccines will play a critical strategic role in achieving the 2030 global goal of rabies eradication.关键词
狂犬病/狂犬病mRNA疫苗/mRNA结构/mRNA递送Key words
Rabies/Rabies mRNA vaccine/mRNA structure/mRNA delivery分类
农业科技引用本文复制引用
焦文杰,印春生,王诗妍,张石豪,倪静颖,韩凤烨,赵丹楠..狂犬病mRNA疫苗的研究进展[J].中国兽药杂志,2025,59(5):61-68,8.
