肿瘤药学2025，Vol.15Issue(2)：152-160,9.DOI:10.3969/j.issn.2095-1264.2025.02.02
MDMX:结构、功能、调控及其抑制剂的研究进展
MDMX:advances in structure,function,regulation and its inhibitors
摘要
Abstract
Murine double minute X(MDMX)is an oncogenic protein which is aberrantly overexpressed in multiple ma-lignant tumors,and its overexpression is closely associated with poor patient prognosis.In-depth elucidation of its function-al mechanisms and regulatory networks holds significant importance for developing novel anticancer drugs targeting MDMX as a druggable vulnerability.However,due to the unique structural characteristics of MDMX,the development of MDMX in-hibitors currently faces many challenges,such as poor specificity and insufficient activity.Overcoming these bottlenecks has become a critical research focus and challenge in this field.In recent years,emerging technologies represented by prote-olysis-targeting chimeras(PROTAC)have demonstrated unique advantages and achieved preliminary progress in this area.This review systematically summarizes the research progress of the structural characteristics,biological functions,regulato-ry networks and targeting inhibitors of MDMX,aiming to provide valuable insights for mechanistic research and therapeutic strategy optimization in related diseases.关键词
MDMX/结构/生物学功能、调控/转录调控/肿瘤治疗/抑制剂Key words
MDMX/Structure/Biological function/Regulation/Transcriptional regulation/Cancer treatment/Inhibitor分类
医药卫生引用本文复制引用
刘书琪,王洪波..MDMX:结构、功能、调控及其抑制剂的研究进展[J].肿瘤药学,2025,15(2):152-160,9.基金项目
国家自然科学基金项目(82273969、82473967). （82273969、82473967）
