肿瘤药学2025，Vol.15Issue(2)：161-168,8.DOI:10.3969/j.issn.2095-1264.2025.02.03
DNA聚合酶θ的生物学特性及其小分子抑制剂在肿瘤中的研究进展
The biological characteristics of DNA polymerase θ and its small molecule inhibitors research progress in tumors
张瑶 1王娟 1李敏 2杨丽瑶 3邹辉 4段华新 1范莎莎1
作者信息
- 1. 湖南师范大学附属第一医院/湖南省人民医院 肿瘤科,湖南 长沙,410013
- 2. 湖南省财贸医院 肿瘤科,湖南 长沙,410013
- 3. 娄底市第一人民医院 肿瘤科,湖南 娄底,417000
- 4. 湖南师范大学 医学部,湖南 长沙,410013
- 折叠
摘要
Abstract
DNA polymerase θ(POLQ),a critical member of the DNA polymerase family,It plays a key role in the dou-ble strand breaks(DSB)repair mediated by microhomology-mediated end-joining(MMEJ).Early studies indicate that POLQ exerts essential biological functions by maintaining genomic stability and suppressing mutagenesis.Its aberrant over-expression in various cancers is closely associated with tumor cell proliferation,apoptosis,radiosensitivity,and drug resis-tance.Small-molecule inhibitors targeting POLQ have emerged as promising tools,offering novel therapeutic strategies for cancer treatment.This review summarizes the biological characteristics of POLQ,its mechanisms in tumorigenesis and pro-gression,and recent advances in small-molecule inhibitors,providing a theoretical foundation for understanding tumor pathogenesis,prognosis,and developing more effective therapies.关键词
POLQ/DNA损伤修复/基因组稳定性/合成致死/靶向治疗Key words
DNA polymerase θ/DNA damage repair/Genome stability/Synthetic lethality/Taeget therapy分类
医药卫生引用本文复制引用
张瑶,王娟,李敏,杨丽瑶,邹辉,段华新,范莎莎..DNA聚合酶θ的生物学特性及其小分子抑制剂在肿瘤中的研究进展[J].肿瘤药学,2025,15(2):161-168,8.
