肿瘤药学2025，Vol.15Issue(2)：169-177,9.DOI:10.3969/j.issn.2095-1264.2025.02.04
新型KRAS突变体抑制剂抗胰腺癌的作用研究
Study on the effects of novel KRAS mutant inhibitors on pancreatic cancer
摘要
Abstract
Objective To delineate the effects of the novel KRAS mutant inhibitor JQC series compounds(JQC-001 to JQC-006)on pancreatic cancer.Methods The inhibitory effects of JQC compounds on the proliferation of KRAS-mutant tumor cells(DU 145,A549,PANC-1,HCT-116)were evaluated using the MTT assay.RT-qPCR was performed to assess the impact of JQC-005 on KRAS mRNA expression in PANC-1 cells.A PANC-1 xenograft nude mouse model was estab-lished to evaluate the in vivo antitumor activity of JQC-005.Results With the exception of JQC-004,the remaining JQC se-ries compounds(JQC-001,JQC-002,JQC-003,JQC-005,JQC-006)were found to inhibit the proliferation of human pros-tate cancer DU 145 cells,human non-small cell lung cancer A549 cells,human pancreatic cancer PANC-1 cells,and hu-man colon cancer HCT-116 cells in a dose-dependent manner.JQC-005 significantly down-regulated the expression of KRAS mRNA in PANC-1 cells,and markedly suppressed tumor growth in the PANC-1 xenograft nude mouse model.Con-clusion The JQC series compounds,particularly JQC-005,exhibit significant anti-pancreatic cancer effects,potentially mediated through regulation of KRAS mutant activity.关键词
JQC系列化合物/胰腺癌/KRAS突变体/新型KRAS突变体抑制剂Key words
JQC series compounds/Pancreatic cancer/KRAS mutant/Novel KRAS mutant inhibitors分类
医药卫生引用本文复制引用
罗桂芳,陈攀,刘晓雨,胡舒洁,杨小平..新型KRAS突变体抑制剂抗胰腺癌的作用研究[J].肿瘤药学,2025,15(2):169-177,9.基金项目
湖南师范大学生殖健康与转化医学研究团队资助项目(2023JC101). （2023JC101）
