肿瘤药学2025，Vol.15Issue(2)：197-204,8.DOI:10.3969/j.issn.2095-1264.2025.02.07
小细胞肺癌化疗及免疫治疗耐药机制的研究进展
Research progress on the mechanisms of chemotherapy and immunotherapy resistance in small cell lung cancer
摘要
Abstract
Small cell lung cancer(SCLC)is a high-grade neuroendocrine carcinoma characterized by rapid growth and metastasis.Treatment-naïve SCLC patients exhibit high sensitivity to chemotherapy,and platinum-based chemotherapy can significantly improve their survival rate.However,most patients are prone to develop drug resistance and relapse after chemotherapy,leading to their poor prognosis.In recent years,immunotherapy has emerged as a novel strategy for the treat-ment of SCLC by activating or enhancing the patient's own immune system to identify and attack tumor cells,yet it also fac-es challenges of resistance.Therefore,the study of the resistance mechanism underlying chemotherapy and immunotherapy is still crucial for understanding and overcoming drug resistance phenomenon and guiding clinical individualized treatment.This review will summarize current chemotherapy and immunotherapy approaches for SCLC,elucidate their respective re-sistance mechanisms,and highlight recent advances in immunotherapy,and further discuss the post-resistance treatment strategy,in order to explore better intervention measures for the treatment of SCLC.关键词
小细胞肺癌/化疗/免疫治疗/耐药性/研究进展Key words
Small cell lung cancer/Chemotherapy/Immunotherapy/Resistance/Research progress分类
医药卫生引用本文复制引用
米克日阿依·艾合买提,帕提古力·阿尔西丁,刘俊远..小细胞肺癌化疗及免疫治疗耐药机制的研究进展[J].肿瘤药学,2025,15(2):197-204,8.基金项目
新疆维吾尔自治区自然科学基金面上项目(2022D01C294). （2022D01C294）
