肿瘤药学2025，Vol.15Issue(2)：205-210,6.DOI:10.3969/j.issn.2095-1264.2025.02.08
铂类药物溶媒要求差异性原因分析
Analysis of the causes for variation in solvent selection of platinum-based drugs
刘馨 1邱益琼 2夏雷3
作者信息
- 1. 贵航贵阳医院药剂科,贵州 贵阳,550009
- 2. 长寿区中医院检验科,重庆,401220
- 3. 重庆医科大学附属儿童医院儿研所,重庆,400010
- 折叠
摘要
Abstract
The chemical stability of platinum-based drugs is a critical factor influencing the selection of solvent media,primarily determined by the stability of their coordination chemistry structures.The stability order of platinum-based drugs is as follows:lobaplatin,oxaliplatin>carboplatin,nedaplatin>cisplatin.Cisplatin and nedaplatin,due to their structural instability,are suitable for use with 0.9%sodium chloride injection as the solvent medium.In contrast,carboplatin,lobapla-tin,and oxaliplatin,which are structurally stable,are more appropriately administered with 5%glucose injection as the sol-vent medium.关键词
铂类药物/溶媒/配位化合物/螯合物/稳定性Key words
Platinum drugs/Solvent medium/Coordination compounds/Chelate/Stability分类
临床医学引用本文复制引用
刘馨,邱益琼,夏雷..铂类药物溶媒要求差异性原因分析[J].肿瘤药学,2025,15(2):205-210,6.
