肿瘤药学2025，Vol.15Issue(2)：229-236,8.DOI:10.3969/j.issn.2095-1264.2025.02.11
谷胱甘肽过氧化物酶4调控结肠癌铁死亡的作用机制及其对预后的影响
The mechanisms of glutathione peroxidase 4 in regulating ferroptosis in colon cancer and its impact on prognosis
摘要
Abstract
Objective To explore the potential mechanisms of glutathione peroxidase 4(GPX4)in regulating ferroptosis in colon cancer and its impact on prognosis using bioinformatics techniques.Methods We collected the clinical data and transcriptome data of colon cancer patients from TCGA and GEO databases,analyzed the differential expression of GPX4 in colon cancer tissues and normal tissues,analyzed the immunohistochemistry results of GPX4 in colon cancer and normal tissues through HPA database,evaluated the relationship between GPX4 expression level and overall survival by KM sur-vival curve,and determined the biological function of GPX4-related genes by GO and KEGG enrichment analysis.The pre-dictive value of GPX4 in colon cancer was evaluated by nomogram,ROC curve and calibration curve.Results GPX4 ex-pression is upregulated in a variety of cancers,and patients with high GPX4 expression in colon cancer have shorter surviv-al time.The main biological functions of GPX4-related genes are related to"toxic substance response","cellular detoxifi-cation","cellular oxidant detoxification"and"antioxidant activity",and GPX4-related genes are enriched in"glutathione metabolism","ferroptosis","arachidonic acid metabolism","selenocompound metabolism"and"thyroid hormone synthe-sis".Evaluation using calibration curves and time-dependent ROC analysis demonstrated that the nomogram model incor-porating GPX4 expression and age effectively predicted 1-,3-,and 5-year survival rates in patients with colon cancer.Conclusion GPX4 is highly expressed in colon cancer and is closely related to the poor prognosis of patients.GPX4 may af-fect the progression of colon cancer through ferroptosis-related pathways,and can be used as a potential biomarker for the prognosis evaluation of colon cancer.关键词
结肠癌/GPX4/铁死亡/预后Key words
Colon cancer/GPX4/Ferroptosis/Prognosis分类
临床医学引用本文复制引用
肖丹,向春红,伍磊,舒采亮,朱智余,刘建新,杨子谊,龚建平,杨娜..谷胱甘肽过氧化物酶4调控结肠癌铁死亡的作用机制及其对预后的影响[J].肿瘤药学,2025,15(2):229-236,8.基金项目
湖南省卫生健康委科研课题(D202302048685). （D202302048685）
