摘要
Abstract
Objective:To explore the effect of Liraglutide,Saxagliptin and Glargine Insulin in the treatment of type 2 diabetes mellitus(T2DM)patients with poor glycemic control.Method:A total of 135 T2DM patients with poor glycemic control who treated in Songzi Traditional Chinese Medicine Hospital from February 2021 to November 2023 were selected,the patients were divided into group A,group B and group C according to the random number table method,45 cases in each group.Group A was treated with Saxagliptin,group B was treated with Liraglutide,and group C was treated with Glargine Insulin,after 12 weeks of treatment,the blood glucose levels,morphological indexes,islet function,renal function and incidence of adverse reactions were compared among three groups.Result:After treatment,the fasting blood glucose,glycosylated hemoglobin and 2 h postprandial blood glucose levels among three groups were lower than those before treatment,and the differences were statistically significant(P<0.05);however,there were no significant differences in the fasting blood glucose,glycosylated hemoglobin and 2 h postprandial blood glucose levels among three groups after treatment(P>0.05).After treatment,the waist circumference and body mass index(BMI)of group B were lower than those before treatment,and the waist circumference and BMI of group B were lower than those of group A and group C,the waist circumference and BMI among three groups after treatment were compared,the differences were statistically significant(P<0.05).After treatment,the insulin resistance index among three groups were lower than those before treatment,and the β-cell function index were higher than those before treatment,and the β-cell function index of group A and group B were higher than that of group C,the difference of the β-cell function index among the three groups after treatment,the differences were statistically significant(P<0.05).After treatment,the levels of serum creatinine and cystatin C in group A were lower than before treatment,and the levels of serum creatinine and cystatin C in group A were lower than those in group B and group C,the serum creatinine and cystatin C among three groups after treatment were compared,and the differences were statistically significant(P<0.05).There was significant difference in the incidence of adverse reactions among three groups(P<0.05);the incidence of gastrointestinal reactions in group B was higher than those in group A and group C,and the incidence of hypoglycemia in group C was higher than those in group A and group B,the differences were statistically significant(P<0.05).Conclusion:Saxagliptin,Liraglutide and Glargine Insulin can effectively improve the blood glucose level of T2DM patients with with poor glycemic control.Saxagliptin can improve renal function and islet function,and has less adverse reactions;Liraglutide can improve the morphology and islet function of patients,but it is prone to gastrointestinal reactions;Glargine insulin has a high incidence of hypoglycemia.关键词
2型糖尿病/利拉鲁肽/甘精胰岛素/沙格列汀/血糖/胰岛功能Key words
Type 2 diabetes mellitus/Liraglutide/Glargine insulin/Saxagliptin/Blood glucose/Islet function
