摘要
Abstract
Objective:To investigate the effect of Shexiang Baoxin Pills combined with Tirofiban on patients with acute myocardial infarction(AMI)undergoing percutaneous coronary intervention(PCI).Method:Sixty patients with AMI undergoing PCI admitted to Fujian Tingzhou Hospital from January 2020 to January 2024 were selected and randomly divided into observation group(n=30)and control group(n=30).The two groups were treated with PCI,the control group was treated with Tirofiban,and the observation group was treated with Shexiang Baoxin Pills on the basis of the control group.Symptom scores,endothelial function,adverse reactions and restenosis were measured before and after intervention between the two groups.Result:After treatment,the scores of traditional Chinese medicine symptoms in both groups were lower than before treatment,and the scores of traditional Chinese medicine symptoms in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,nitric oxide(NO)increased in both groups than those before treatment,and the index in the observation group was higher than that in the control group,and endothelin-1(ET-1)and von Willebrand factor(vWF)decreased in both groups than those before treatment,and the indexes in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)of the two groups were higher than those before treatment,and the observation group was higher than that in the control group,left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)decreased than those before treatment,and the indexes in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 8 months of follow-up,the stent restenosis rate in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:For AMI patients undergoing PCI,the combination of Shexiang Baoxin Pills and Tirofiban can achieve good results,improve symptoms,signs and vascular endothelial function,enhance cardiac function,reduce the incidence of stent restenosis,and do not increase the occurrence of adverse reactions.关键词
急性心肌梗死/经皮冠状动脉介入术/麝香保心丸/替罗非班/血管内皮功能/心功能Key words
Acute myocardial infarction/Percutaneous coronary intervention therapy/Shexiang Baoxin Pills/Tilofiban/Endothelial function of blood vessels/Heart function
