中西医结合肝病杂志2025，Vol.35Issue(5)：529-537,9.DOI:10.3969/j.issn.1005-0264.2025.005.001
肪组织功能障碍对代谢相关性脂肪性肝病的影响及防治策略
Research on the impact of adipose tissue dysfunction on MAFLD and its prevention and treatment strategies
摘要
Abstract
Metabolic associated fatty liver disease(MAFLD)is a chronic liver disease characterized by hepatic steatosis caused by metabolic disorders,and its progression leading to inflammation and fibrosis of the liver.It is closely associated with the development of metabolic diseases such as cirrhosis,hepatocellular carcinoma,obesity,type 2 diabetes,and cardiovascular diseases.Reduced metabolic flexibility,inflammation,and abnormal secretion of adipokines mediated by adipose tissue dysfunction are key factors driving the progression of MAFLD.Different types of adipose tissues play distinct roles in the pathogenesis of MAFLD.Substantial studies have confirmed that brown adipose tissue can ameliorate metabolic disorders by enhancing systemic insulin sensitivity and regulating lipid metabolism.Therefore,reducing the excessive accumulation of white adipose tissue and regulating the browning of white adipose tissue might serve as critical strategies for MAFLD treatment.This review focuses on adipose tissue,elucidating the effects and mechanisms of adipose tissue dysfunction on the development of MAFLD,as well as summarizing the latest advances,challenges,and major issues in current therapies targeting adipose tissue dysfunction.关键词
代谢相关性脂肪性肝病/白色脂肪组织/棕色脂肪组织/代谢Key words
metabolic associated fatty liver disease/white adipose tissue/browning adipose tissue/metabolism分类
医药卫生引用本文复制引用
范慧倩,杨博雯,杨玲..肪组织功能障碍对代谢相关性脂肪性肝病的影响及防治策略[J].中西医结合肝病杂志,2025,35(5):529-537,9.基金项目
国家自然科学基金面上项目(No.82270614、81974078、81570530),科技部重点研发项目(2023YFC2413804),湖北省科技厅重点项目(No.2019ACA133) （No.82270614、81974078、81570530）
