遵义医科大学学报2025，Vol.48Issue(5)：498-514,17.
ILAE分型海马硬化的多轴互作机制:表观-血管-菌群跨尺度解析与精准干预
Multiaxial crosstalk in ILAE hippocampal sclerosis:cross scale epigenetic-vas-cular-microbiome dynamics for precision therapy
摘要
Abstract
As the core unit of the limbic system,the hippocampus is involved in the regulation of higher neural activity by integrating emotional encoding and memory storage functions.In the pathological process of epilepsy,structural remodeling and functional disorders in this region have become the focus of research,and the existing evidence mostly focuses on hippocampal sclerosis,a typical neurodegenerative change.However,there is still a lack of systematic analysis of the pathological subtypes under the International League Against Epilepsy(ILAE)classification system in cross-scale molecular events such as epigenetic regulation and microbiome-brain axis.By integrating clinical cohort data and experimental model evidence,this article focuses on the association character-istics between hippocampal sclerosis subtypes and seizure patterns,and reveals the formation of abnormal hipp-ocampal network and the cascading effect of abnormal hippocampus-related neurotransmitters in the formation of epileptogenic network.The study found that specific pathological subtypes showed a significant correspondence with seizure frequency and drug sensitivity,suggesting that hippocampal sclerosis drives epilepsy progression through multidimensional molecular events.In the future,it is necessary to combine spatial transcriptome and targeted metabolomics technology to analyze the cell interaction network in the hippocampal microenvironment,so as to provide a theoretical basis for the development of subtype-specific antiepileptic strategies.关键词
海马硬化/癫痫/国际抗癫痫联盟分类/神经递质/神经血管/表观遗传调控/微生物组-脑轴Key words
hippocampal sclerosis/epilepsy/International League Against Epilepsy classification/neurotrans-mitters/neurovascular/epigenetic regulation/microbiome-brain axis分类
临床医学引用本文复制引用
张良雪,张骏,徐祖才..ILAE分型海马硬化的多轴互作机制:表观-血管-菌群跨尺度解析与精准干预[J].遵义医科大学学报,2025,48(5):498-514,17.基金项目
国家自然科学基金资助项目(NO:82360268、82471487) （NO:82360268、82471487）
贵州省癫痫基础与临床研究科技创新人才团队项目[NO:CXTD(2022)013]. （2022）
