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Single-Cell Transcriptomic Profiling Reveals KRAS/TP53-Driven Neutrophil Reprogramming in Luad:A Multi-Gene Prognostic Model and Therapeutic Targeting of RHOV

Yinghui Ye Yulou Luo Yutian Sun Yujie Zhang Jiaxin Lin Ziling Yang Anping Xu Bei Xue

Oncology Research2025，Vol.33Issue(6)：P.1383-1404,22.

Oncology Research2025，Vol.33Issue(6)：P.1383-1404,22.DOI:10.32604/or.2025.062584

Single-Cell Transcriptomic Profiling Reveals KRAS/TP53-Driven Neutrophil Reprogramming in Luad:A Multi-Gene Prognostic Model and Therapeutic Targeting of RHOV

Yinghui Ye ¹Yulou Luo ²Yutian Sun ³Yujie Zhang ¹Jiaxin Lin ⁴Ziling Yang ⁵Anping Xu ⁶Bei Xue¹

作者信息

1. Department of Laboratory Medicine,Xinhua Hospital,Shenzhen,518000,China
2. Department of Breast Surgery,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi,830000,China
3. Department of Medical Oncology,Sichuan Cancer Hospital and Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu,610000,China
4. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen,518000,China
5. Medical College,Shantou University,Shantou,515000,China
6. Department of Laboratory Medicine,Shenzhen Hospital,Peking University,Shenzhen,518000,China
折叠

摘要

关键词

Lung adenocarcinoma(LUAD)/KRAS/TP53 mutations/neutrophil/prognosis/tumor microenvironment/single-cell analysis

分类

医药卫生

引用本文复制引用

Yinghui Ye,Yulou Luo,Yutian Sun,Yujie Zhang,Jiaxin Lin,Ziling Yang,Anping Xu,Bei Xue..Single-Cell Transcriptomic Profiling Reveals KRAS/TP53-Driven Neutrophil Reprogramming in Luad:A Multi-Gene Prognostic Model and Therapeutic Targeting of RHOV[J].Oncology Research,2025,33(6):P.1383-1404,22.

基金项目

supported by Zhongnanshan Medical Foundation of Guangdong Province(No.ZNSXS-20240108 to Anping Xu). （No.ZNSXS-20240108 to Anping Xu）

Oncology Research

ISSN：0965-0407

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