癌变·畸变·突变2025，Vol.37Issue(3)：215-220,6.DOI:10.3969/j.issn.1004-616x.2025.03.007
复方丹参制剂对伊马替尼在大鼠体内代谢的影响
Effect of Danshen preparation on blood concentration of imatinib in rats
摘要
Abstract
OBJECTIVE:This study aimed to investigate effect of Danshen(Salvia miltiorrhiza)preparation on blood concentration of imatinib and N-desmethyl imatinib in rats.METHODS:Healthy male SD rats were randomly divided into three groups of 10 per group:control,Danshen tablet of 486 mg/kg and Danshen dripping pill of 72.9 mg/kg.All three groups were given imatinib at 30 mg/kg.Each group was given by intragastric administration for 14 consecutive days.Plasma samples were collected on day 1 and day 14.Blood concentrations of imatinib and N-desmethyl imatinib were determined by ultra-performance liquid chromatography-mass spectrometry(HPLC-MS/MS).Calculation of pharmacokinetic parameters of imatinib and N-desmethyl imatinib using DAS 2.0 software.RESULTS:On the 1st day after administration,the area under the concentration-time curve(AUC0-∞)of imatinib in the compound Danshen tablet group was reduced by 19.00%(P<0.05)compared with the control group.On the 14th day after administration,the AUC0-24 and peak concentration(Cmax)of imatinib in the compound Danshen tablet group were reduced by 19.45%and 17.84%,respectively(P<0.05).The AUC0-24 and AUC0-∞ of N-desmethylimatinib were reduced by 29.87%and 35.27%,respectively(P<0.05).On the 1st and 14th days after administration,there were no significant differences in the pharmacokinetic parameters of imatinib and N-desmethylimatinib between the compound Danshen dripping pill group and the control group(P>0.05).CONCLUSION:Compound Danshen tablets affected the plasma concentrations of imatinib in rats while compound Danshen dripping pills had no significant effect on the concentrations of imatinib and N-desmethylimatinib in rat plasma.关键词
伊马替尼/N-去甲基伊马替尼/复方丹参片/复方丹参滴丸Key words
imatinib/N-desmethyl imatinib/compound Danshen tablet/compound Danshen drip pill分类
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范娜灵,郭雅,郭腾,刘明峰,杜丽英,陈欣然..复方丹参制剂对伊马替尼在大鼠体内代谢的影响[J].癌变·畸变·突变,2025,37(3):215-220,6.基金项目
河北省科学技术厅民生科技专项(20377757D) （20377757D）
