摘要
Abstract
Massive hemorrhage is one of the major causes of trauma death,and effective control of hemostasis is crucial to reduce mortality of trauma patients.Therefore,novel hemostatic materials of being safe and high efficacy are urgently needed for the use in surgical operations as well as in emergency.Chitosan is a natural polymer derived from deacetylation of chitin,owing to its excellent biocompatibility,biodegradability,non-toxicity,antimicrobial activity,wound-healing capability,it has been extensively applied in the biomedical field.Consequently,chitosan-based composite hemostatic materials has been found to be research hotspots.In this paper,the hemostatic mechanism of chitosan is described,and the recent research progress in composite hemostatic materials of various forms,such as sponges,hydrogels,films,particles/powders and fabrics based on chitosan and its derivatives is reviewed,including a brief summary of technical methods,properties,mechanisms of action,relative efficacy,application scenarios and so on.Through synergistic interaction with two or more hemostatic mechanisms,the hemostatic properties of chitosan composite hemostatic materials are significantly enhanced compared with pure chitosan,in addition,its mechanical properties,solubility,antibacterial properties and pro-healing properties are also improved.Finally,the application prospect of chitosan based composite hemostatic materials is prospected,and the main challenges are discussed in order to provide reference for the follow-up research.关键词
壳聚糖/复合止血材料/止血机制/海绵/水凝胶Key words
chitosan/composite hemostatic materials/hemostatic mechanism/sponge/hydrogel分类
基础医学
