分析测试学报2025，Vol.44Issue(6)：1202-1207,6.DOI:10.12452/j.fxcsxb.25011118
评价中药指纹图谱批次相似性的h多重相似性指数
An h Multiple Similarity Index for Assessing the Batch Similarity of Chinese Medicine Fingerprints
摘要
Abstract
An h multiple similarity index(HMSI)was proposed to evaluate batch consistency of tradi-tional Chinese medicine fingerprints.HMSI was defined as follows:for the pairwise similarity of all objects in a batch(ranged from[0,1]),if M%of all the pairwise similarity values is not less than M%,then the value of HMSI is M%.Based on the high-performance liquid chromatography(HPLC)fingerprints of Radix Ophiopogon japonicus(Maidong)and Qingwei Huanglian Pills,the proposed HMSI was used to evaluate the quality consistency of different batches of Chinese herbal medicines,and the results were compared with those obtained by average similarity and median similarity.The results indicated that HMSI was suitable for HPLC fingerprints and was more reasonable to evaluate batch consistency than average similarity and median similarity.The index considers the similarity in-tensity of samples in a batch,as well as the number of samples with high similarity.HMSI is a sim-ple,robust,easy-to-calculate and comprehensive index to evaluate batch consistency of traditional Chinese medicine fingerprints.关键词
中药/指纹图谱/批次一致性/h多重相似性指数/相似性评价/高效液相色谱Key words
traditional Chinese medicine/fingerprints/batch consistency/h multiple similarity index/similarity evaluation/high-performance liquid chromatography分类
化学引用本文复制引用
朱浩宇,顾荣领,杜士杰,徐路..评价中药指纹图谱批次相似性的h多重相似性指数[J].分析测试学报,2025,44(6):1202-1207,6.基金项目
国家自然科学基金资助项目(82260896) （82260896）
