海南医科大学学报2025，Vol.31Issue(11)：872-880,9.DOI:10.13210/j.cnki.jhmu.20250227.001
多能干细胞在肺纤维化治疗和研究中的应用
Application of pluripotent stem cell in the treatment and study of pulmonary fibrosis
摘要
Abstract
Pulmonary fibrosis(PF)is a chronic,progressive lung disease for which current treatments only partially alleviate clinical symptoms but cannot reverse fibrosis progression or cure the disease.Compared with traditional models and drug screening systems for pulmonary fibrosis,models and systems derived from pluripotent stem cells can better simulate the physiological char-acteristics and microenvironment of fibrosis,and also provide new means for subsequent treatment of fibrosis.This review summa-rizes the contributions of pluripotent stem cells-based models and drug screening systems for pulmonary fibrosis and their progress in treatment research,and discusses the challenges and solutions for their clinical translation.关键词
肺纤维化/间质性肺病/特发性肺纤维化/干细胞/多能干细胞/胚胎干细胞/诱导多能干细胞Key words
Pulmonary fibrosis/Interstitial lung disease/Idiopathic pulmonary fibrosis/Stem cell/Pluripotent stem cell/Embryonic stem cell/Induced pluripotent stem cell分类
临床医学引用本文复制引用
翁冬,王艳阳,王诺鑫,何志旭..多能干细胞在肺纤维化治疗和研究中的应用[J].海南医科大学学报,2025,31(11):872-880,9.基金项目
This study was supported by National Natural Science Foundation of China(32270848) （32270848）
Ministry of Education Coordination Innovation Center Construction Project:Provincial-Ministry Coordination Innovation Center for Tissue Damage Repair and Regenerative Medicine(JiaoKeXueYan[2020]39) （JiaoKeXueYan[2020]39）
Guizhou Science and Technology Support Plan Project(QianKexiYun[2020]4Y192) （QianKexiYun[2020]4Y192）
Guizhou High-level Innovative Talent Cultivation Project(QianCengCi) 国家自然科学基金资助项目(32270848) （QianCengCi）
教育部协同创新中心建设项目:组织损伤修复与再生医学省部共建协同创新中心[教科技函(2020)39号] （2020）
贵州省科技支撑计划项目[黔科合支撑(2020)4Y192号] （2020）
贵州省高层次创新人才培养项目(千层次) （千层次）
