广州医药2025，Vol.56Issue(5)：616-621,6.DOI:10.20223/j.cnki.1000-8535.2025.05.006
可注射型载阿霉素水凝胶治疗胶质瘤的实验研究
Experimental study on the treatment of glioma with injectable doxorubicin hydrogel
摘要
Abstract
Objective To investigate the therapeutic effect of injectable doxorubicin-containing hydrogel on glioma.Methods The release of doxorubicin hydrogel in vitro was detected by dialysis.The subcutaneous C6 glioma model of rats was constructed and divided into blank control group,intravenous injection group and hydrogel group according to different administration methods.The distribution of doxorubicin in the tumor was detected by immunofluorescence 15 hours after administration.After 7 days of administration,the tumor inhibition rate of each group was calculated.The tumor tissue was stained with hematoxylin eosin.Results In vitro,doxorubicin-containing hydrogels had sustained drug release properties.In vivo,compared with intravenous administration,local injection of doxorubicin-containing hydrogel resulted in more doxorubicin distribution,higher tumor inhibition rate(42%vs 64%)and more obvious tumor cell necrosis.Conclusions Doxorubicin-containing hydrogel can provide a new carrier for local chemotherapy of glioma.关键词
可注射型/阿霉素/水凝胶/治疗/胶质瘤Key words
injectable/doxorubicin/hydrogel/treatment/glioma引用本文复制引用
李伟,王业忠,胡滨,姬云翔,柯炎斌..可注射型载阿霉素水凝胶治疗胶质瘤的实验研究[J].广州医药,2025,56(5):616-621,6.基金项目
广东省医学科研基金(A2023213) （A2023213）
广州市卫生健康科技一般引导项目(20221A011081) （20221A011081）
