广州医药2025，Vol.56Issue(5)：689-693,5.DOI:10.20223/j.cnki.1000-8535.2025.05.017
淋巴细胞亚群在鉴别低增生性骨髓增生异常综合征和再生障碍性贫血中的价值
The value of lymphocyte subpopulations in differentiation between hypoplastic myelodysplastic syndrome and aplastic anemia
刘冰 1许惠丽 1王敏芳1
作者信息
- 1. 平顶山市第一人民医院血液淋巴瘤科(河南 平顶山 467000)
- 折叠
摘要
Abstract
Objective To explore the value of lymphocyte subsets in differentiation between hypoplastic myelodysplastic syndrome(hypo MDS)and aplastic anemia(AA).Methods A retrospective analysis was conducted on 80 patients with hypo MDS and AA who underwent treatment in the First People's Hospital of Pingdingshan City from July 2020 to June 2023.Among them,there were 48 cases of hypo MDS and 32 cases of AA.The differences in lymphocytes(CD3+,CD4+,CD8+,CD4+/CD8+,CD3+CD57+T-large granular lymphocytes,CD3-CD16/CD56+natural killer cells,and CD19+B lymphocytes)between the two groups of patients were analyzed.Results There was no statistically significant difference in CD3+(78.42±8.02)%between the hypo MDS group and the AA group(75.65±8.44)%(P＞0.05).The CD4+(47.54±6.88)%and CD4+/CD8+(2.16±0.61)%in the hypo MDS group were higher than those in the AA group(40.11±5.71)%and(1.49±0.48)%,respectively.The CD8+(23.12±6.42)%was lower than that in the AA group(31.77±6.79)%(P＜0.05).The levels of CD3+CD57+T-large granular lymphocytes(13.45±3.77)%and CD3-CD16/CD56+natural killer cells(12.32±3.97)%in hypo MDS patients were higher than those in the AA group([9.77±2.15]%,[8.84±2.11]%),and CD19+B lymphoid cells(9.75±2.08)%were lower than that in the AA group([12.65±3.35]%,P＜0.05).Conclusions The changes in lymphatic subpopulations can be used for the differential diagnosis of AA or hypo MDS.关键词
淋巴细胞亚群/低增生性骨髓增生异常综合征/再生障碍性贫血/大颗粒淋巴细胞Key words
lymphocyte subpopulations/hypoproliferative myelodysplastic syndrome/aplastic anemia/large granular lymphocytes引用本文复制引用
刘冰,许惠丽,王敏芳..淋巴细胞亚群在鉴别低增生性骨髓增生异常综合征和再生障碍性贫血中的价值[J].广州医药,2025,56(5):689-693,5.
