实用临床医药杂志2025，Vol.29Issue(9)：101-105,5.DOI:10.7619/jcmp.20243005
司库奇尤单抗联合莪仙化斑汤对斑块型银屑病患者中医证候积分及甲皱襞微循环形态的影响
Effect of secukinumab combined with E'xian Huaban Decoction on traditional Chinese medicine symptom scores and nailfold microcirculation morphology in patients with plaque psoriasis
摘要
Abstract
Objective To investigate the effects of secukinumab combined with E'xian Huaban decoction on traditional Chinese medicine symptom scores and nailfold microcirculation morphology in patients with plaque psoriasis.Methods A total of 120 patients with plaque psoriasis were selected and randomly divided into monotherapy group(n=60)and combination therapy group(n=60).The monotherapy group received secukinumab treatment,while the combination therapy group was treated with secukinumab plus E'xian Huaban Decoction.Clinical therapeutic efficacy,traditional Chinese medicine symptom scores(including skin lesions,pruritus,rough skin,scales and irritabili-ty),relevant scale[Psoriasisarea and Severity Index(PASI),Dermatology Life Quality Index(DLQI)and Visual Analogue Scale(VAS)]scores,inflammatory factors[interleukin-17(IL-17),interleukin-23(IL-23)and vascular endothelial growth factor(VEGF)]levels and nailfold microcircu-lation morphology(loop tube morphology,blood flow state and loop periphery state)were observed in both groups.Results The overall clinical efficacy rate in the combination therapy group was 95.00％,which was significantly higher than 83.33％ in the monotherapy group(P＜0.05).After treatment,traditional Chinese medicine symptom scores(skin lesions,pruritus,rough skin,scales and irritability),inflammatory factors(IL-17,IL-23 and VEGF)levels,scale(PASI,DLQI and VAS)scores as well as loop tube morphology scores,blood flow state scores and loop periphery state scores were signifi-cantly lower compared to pre-treatment values,and these parameters were significantly lower in the combination therapy group than the monotherapy group(P＜0.05).Conclusion Secukinumab combined with E'xian Huaban Decoction can significantly improve clinical symptoms and signs,and enhancing the clinical therapeutic effect.关键词
斑块化银屑病/司库奇尤单抗/莪仙化斑汤/中医证候积分/甲皱襞微循环形态/银屑病面积和严重程度指数/视觉模拟评分法/炎症因子水平Key words
plaque psoriasis/secukinumab/E'xian Huaban Decoction/traditional Chinese medicine symptom score/nailfold microcirculation morphology/Psoriasis Area and Severity Index/Visual Analogue Scale/inflammatory factor level分类
临床医学引用本文复制引用
宫安明,姜桂仙,李琳,杨晓丽,孙玉文..司库奇尤单抗联合莪仙化斑汤对斑块型银屑病患者中医证候积分及甲皱襞微循环形态的影响[J].实用临床医药杂志,2025,29(9):101-105,5.基金项目
河北省秦皇岛市科学技术研究与发展计划项目(202301A070) （202301A070）
