实用临床医药杂志2025，Vol.29Issue(9)：124-129,6.DOI:10.7619/jcmp.20245609
微小RNA调节骨关节炎软骨细胞自噬的研究进展
Research progress on regulation of autophagy in osteoarthritis chondrocytes by microRNAs
摘要
Abstract
Osteoarthritis(OA)is a degenerative joint disease primarily characterized by articular cartilage degeneration.Autophagy is a crucial intracellular homeostatic system that plays a vital role in maintaining normal cartilage function.By regulating cell apoptosis and repairing damaged chondro-cytes,autophagy protects cartilage,and dysfunction in chondrocyte autophagy is an important patho-genic mechanism underlying cartilage degeneration in OA.MicroRNAs(miRNA)can regulate gene expression and play a key role in chondrocyte development and functional maintenance.MiRNA in-volved in the regulation of autophagy are aberrantly expressed in OA,suggesting that miRNAs may serve as potential targets and biomarkers for early prediction,diagnosis,and effective treatment of OA.This review discussed the role of autophagy in OA and the regulatory role of miRNA in OA de-velopment,with a focus on the role of miRNA-mediated regulation of chondrocyte autophagy in OA pathogenesis and its potential therapeutic value.关键词
微小RNA/自噬/软骨细胞/骨关节炎/退行性病变/细胞凋亡/治疗靶点/发病机制Key words
microRNA/autophagy/chondrocyte/osteoarthritis/degenerative lesion/cell ap-optosis/therapeutic target/pathogenesis分类
临床医学引用本文复制引用
丁福超,袁普卫,马盼鑫,杨虎..微小RNA调节骨关节炎软骨细胞自噬的研究进展[J].实用临床医药杂志,2025,29(9):124-129,6.基金项目
陕西省中医药管理局"骨退行性疾病中西医结合防治""双链融合""中青年科研创新团队"项目(2022-SLRH-LJ-001) （2022-SLRH-LJ-001）
陕西中医药大学学科建设创新团队项目(2019YL-02) （2019YL-02）
长安医学关中李氏骨伤学术流派传承工作室建设项目(陕中医药发[2018]40号) （陕中医药发[2018]40号）
