菌物学报2025，Vol.44Issue(6)：145-152,8.DOI:10.13346/j.mycosystema.240351
白木香内生真菌Hypoxylon sp.HK-37的次级代谢产物
Secondary metabolites of endophytic fungus Hypoxylon sp.HK-37 from Aquilaria sinensis
摘要
Abstract
Five compounds were isolated from the rice solid fermentation products of Hypoxylon sp.HK-37,an endophytic fungus from Aquilaria sinensis by various separation techniques including silica gel column chromatography,Sephadex LH-20 gel column chromatography,semi-preparative high-performance liquid chromatography(HPLC),and recrystallization.The structures of these compounds were identified through spectroscopic methods in combined with consulting literature data.They were determined as methyl 8-hydroxy-1-oxo-1H-isochromene-3-carboxylate(1),8-hydroxy-1-oxo-1H-isochromene-3-carboxylicacid(2),1,8-dimethoxynaphthalene(3),(-)-5-methylmellein(4),and(-)-6-hydroxymellein(5).Among them,compound 1 is a new compound,compound 2 is a new natural product,and compound 5 is isolated from this genus for the first time.The isolated compounds were tested for their acetylcholinesterase inhibitory activity in vitro,and the results showed that all the compounds exhibited certain inhibitory activity.This research provides reference material for its further development and utilization.关键词
内生真菌/白木香/次级代谢产物/乙酰胆碱酯酶Key words
endophytic fungus/Aquilaria sinensis/secondary metabolites/acetylcholinesterase引用本文复制引用
何开磊,戴好富,吴妃,袁靖喆,谭志琼,陈惠琴..白木香内生真菌Hypoxylon sp.HK-37的次级代谢产物[J].菌物学报,2025,44(6):145-152,8.基金项目
中国热带农业科学院国家热带农业科学中心科技创新团队(CATASCXTD202406) （CATASCXTD202406）
国家中药材产业体系(CARS-21)This work was supported by the Innovation Team of the National Tropical Agricultural Science Center of the Chinese Academy of Tropical Agricultural Sciences(CATASCXTD202406)and the Traditional Chinese Medicine Industry System(CARS-21). （CARS-21）
