实用临床医药杂志2025，Vol.29Issue(10)：14-18,25,6.DOI:10.7619/jcmp.20246182
一项关于子宫内膜异位症与甲状腺癌的双向双样本孟德尔随机化分析
Endometriosis and thyroid cancer:a two-sample mendelian randomization analysis
摘要
Abstract
Objective To investigate the bidirectional causal relationship between endometriosis and thyroid cancer using bidirectional two-sample Mendelian randomization(MR).Methods Ge-nome-wide association study(GWAS)data for endometriosis were obtained from the FinnGen R11 database,and GWAS data for thyroid cancer were sourced from the European Bioinformatics Institute(EMBL-EBI).Single nucleotide polymorphisms(SNPs)that met the requirements were selected as instrumental variables.The inverse variance weighted(IVW)method was employed as the primary analytical approach,supplemented by MR-Egger regression,weighted median method,simple model,and weighted model results.Cochran's Q test,MR-Egger regression intercept analysis,and the leave-one-out method were used to assess the robustness of the results.Results Ultimately,25 SNPs high-ly associated with endometriosis and 3 SNPs highly associated with thyroid cancer were included in this study.The IVW analysis results of the forward MR analysis indicated no significant causal rela-tionship between endometriosis and the risk of thyroid cancer(P=0.50,OR=1.06,95％CI:0.88 to 1.29).This result was also supported by MR-Egger regression,simple model,weighted model,and weighted median analyses(P＞0.05).The IVW analysis results of the reverse MR analysis similarly showed no significant causal relationship between thyroid cancer and the risk of endometrio-sis(P=0.09,OR=1.03,95％CI,0.99 to 1.06).The findings from MR-Egger regression,sim-ple model,weighted model,and weighted median analyses all supported this conclusion(P＞0.05).Conclusion The MR analysis doesn't show a significant bidirectional causal relationship between endometriosis and thyroid cancer.关键词
子宫内膜异位症/甲状腺癌/孟德尔随机化/因果关系/全基因组关联研究/单核苷酸多态性/逆方差加权法/工具变量Key words
endometriosis/thyroid cancer/Mendelian randomization/causal relationship/genome-wide association study/single nucleotide polymorphism/inverse variance weighted method/instrumental variable分类
医药卫生引用本文复制引用
尚怡灿,熊晨宇,黄艳辉..一项关于子宫内膜异位症与甲状腺癌的双向双样本孟德尔随机化分析[J].实用临床医药杂志,2025,29(10):14-18,25,6.基金项目
国家中医药管理局第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号) （国中医药人教函[2022]1号）
湖北省卫生健康委员会2025-2026年度中医药科研重点项目(ZY2025D005) （ZY2025D005）
湖北省武汉市卫生健康委员会医学科研项目(WZ20M02) （WZ20M02）
