实用临床医药杂志2025，Vol.29Issue(10)：19-25,7.DOI:10.7619/jcmp.20245348
不同分子分型乳腺癌患者多模态超声成像特征分析
Analysis of multimodal ultrasound imaging characteristics in patients with different molecular subtypes of breast cancer
摘要
Abstract
Objective To analyze the multimodal ultrasound imaging characteristics in patients with different molecular subtypes of breast cancer.Methods The medical records of 85 patients with breast cancer were retrospectively collected and classified into 12 cases of Luminal A,35 cases of Lu-minal B,21 cases of HER2,and 17 cases of triple-negative breast cancer based on immunohisto-chemical results.All patients underwent conventional ultrasound,color Doppler ultrasound,ultra-sound elastography,and contrast-enhanced ultrasound.The relationship between multimodal ultra-sound characteristics and breast cancer molecular subtypes and their diagnostic value were analyzed.Results Conventional ultrasound and color Doppler ultrasound results showed statistically significant differences in the margin characteristics of breast cancer lesions among the four molecular subtypes(P＜0.05).Ultrasound elastography results revealed that the maximum elastic modulus(Emax)lev-els of HER2 and triple-negative subtypes were higher than those of Luminal A and Luminal B,respec-tively.The ratios of elastic modulus to normal tissue(Eratio)for Luminal B,HER2,and triple-nega-tive subtypes were higher than that of Luminal A,and the Eratio level of Luminal Bwas lower than that of HER2(P＜0.05).Contrast-enhanced ultrasound results showed statistically significant differences in enhancement levels,perfusion defects,and peak intensity(IMAX),time to peak(TTP),and augmentation time(AT)among the four molecular subtypes of breast cancer lesions(P＜0.05).Multivariate Logistic regression analysis showed that margin characteristics,Emax,Emin,Emean,Eratio,IMAX,TTP,and AT were independent influencing factors for breast cancer molecular subtypes(P＜0.05).Receiver operating characteristic curve analysis showed that the area under the curve and sensitivity of multimodal ultrasound imaging characteristics(combined indicators)for diagnosing breast cancer molecular subtypes were significantly greater than those of individual indicators(P＜0.05).Conclusion There are differences in two-dimensional ultrasound,color Doppler ultra-sound,ultrasound elastography,and contrast-enhanced ultrasound results among different molecular-subtypes of breast cancer.Multimodal ultrasound imaging characteristics have high diagnostic value for breast cancer molecular subtypes.关键词
乳腺癌/分子分型/多模态超声成像/彩色多普勒超声/超声弹性成像/超声造影检查/弹性模量/病灶边缘特征Key words
breast cancer/molecular subtypes/multimodal ultrasound imaging/color doppler ultrasound/ultrasound elastography/contrast-enhanced ultrasound/elastic modulus/margin characteristics of lesions分类
医药卫生引用本文复制引用
熊凌厉,黄汇,刘媛媛,樊磊..不同分子分型乳腺癌患者多模态超声成像特征分析[J].实用临床医药杂志,2025,29(10):19-25,7.基金项目
2023年度江苏省南京市江宁区科技惠民计划项目(2023057S) （2023057S）
