实用临床医药杂志2025，Vol.29Issue(10)：52-56,5.DOI:10.7619/jcmp.20245396
肺癌术后假丝酵母菌感染患者血清降钙素原、α1-酸性糖蛋白、簇分化抗原64指数与预后的关系
Relationships of serum procalcitonin,α1-acid glycoprotein and cluster of differentiation 64 index with prognosis in patients with Candida infection after lung cancer surgery
摘要
Abstract
Objective To investigate the relationships of serum procalcitonin(PCT),α1-acid glycoprotein(α1-AGP)and cluster of differentiation 64(CD64)index with the severity of illness and prognosis in patients with pulmonary Candida infection after lung cancer surgery.Methods A pro-spective study was conducted in 120 patients with pulmonary Candida infection after lung cancer sur-gery as infection group,and 60 patients without infection after lung cancer surgery in the same period were selected as control group.Baseline characteristics and laboratory indicators were compared be-tween the two groups.Differences in serum PCT,α1-AGP,CD64 index in peripheral blood,and plasma 1,3-β-D glucan test(BG)were compared among patients with different severities of illness and prognoses in the infection group.The relationship between serum indicators and prognosis as well as their predictive efficiencies were analyzed,and external validation was performed.Results The levels of serum PCT,α1-AGP,CD64 index in peripheral blood,and plasma BG in the infection group were significantly higher than those in the control group(P＜0.05).In the infection group,the levels of serum PCT,α1-AGP,and CD64 gradually decreased significantly in patients with severe,moderate,and mild illness,and the levels of these indicators in dead patients were significantly higher than those in surviving patients(P＜0.05).Survival curve analysis showed that patients with low levels of serum PCT,α1-AGP,and CD64 index before treatment had higher survival rates than those with high levels of these indicators.Receiver operating characteristic(ROC)curve analysis revealed that the combined prediction of PCT,α1-AGP,and CD64 index for mortality was superior to individual indicators or their pairwise combinations,and external validation confirmed the good predictive efficacy of the combined prediction.Conclusion PCT,α1-AGP,and CD64 index are closely related to pulmonary Candida infection after lung cancer surgery,and the combined detection of these indicators has certain predictive value for 28-day prognosis.关键词
假丝酵母菌/降钙素原/α1-酸性糖蛋白/簇分化抗原64/肺癌/术后感染/预后/预测效能Key words
Candida/procalcitonin/α1-acid glycoprotein/cluster of differentiation 64/lung cancer/postoperative infection/prognosis/predictive efficacy分类
医药卫生引用本文复制引用
张会峰,侯天文,郑运周,安黎云,陈晶,刘叶,李军涛,田荣英..肺癌术后假丝酵母菌感染患者血清降钙素原、α1-酸性糖蛋白、簇分化抗原64指数与预后的关系[J].实用临床医药杂志,2025,29(10):52-56,5.基金项目
2018年度河北省医学科学研究重点课题计划(20180919) （20180919）
