实用临床医药杂志2025，Vol.29Issue(10)：57-62,6.DOI:10.7619/jcmp.20245130
干扰素基因刺激因子、C-C模式趋化因子配体5、干扰素调节因子3和细胞程序性死亡配体1在肺鳞癌中的表达及临床意义
Expression and clinical significance of stimulator of interferon genes,C-C motif chemokine ligand 5,interferon regulatory factor 3 and programmed death ligand-1 in squamous cell lung cancer
摘要
Abstract
Objective To analyze the expression and clinical significance of stimulator of interfer-on genes(STING),C-C motif chemokine ligand 5(CCL5),interferon regulatory factor 3(IRF3)and programmed death ligand-1(PDL1)in squamous cell lung cancer.Methods A total of 56 pa-tients with squamous cell lung cancer were enrolled.Resected tumor tissues and adjacent non-tumor tissues(located more than 5 cm from the tumor margin)were collected.Immunohistochemical staining was performed to detect the expression of STING,CCL5,IRF3 and PDL1.The correlations of STING,CCL5,IRF3 and PDL1 with clinical data were analyzed.The relationship between the expression of STING,CCL5,IRF3 and PDL1 in lung squamous cell carcinoma tissues and prognosis was also evalua-ted.The prognostic factors of patients with lung squamous cell carcinoma were analyzed.Results The positive rate of STING expression in lung squamous cell carcinoma tissues was significantly lower than that in adjacent non-tumor tissues,whereas the positive rates of CCL5,IRF3 and PDL1 were significantly higher(P＜0.05).The expression levels of STING,CCL5,IRF3 and PDL1 were associated with tumor diameter,TNM stage,lymph node metastasis and differentiation degree(P＜0.05).The 3-year survival rate of STING positive expression patients was significantly higher than that of STING negative expression patients(P＜0.05).The 3-year survival rate of CCL5 positive,IRF3 positive and PDL1 positive expression patients was significantly lower than that of CCL5 negative,IRF3 negative and PDL1 negative expression patients(P＜0.05).STING,CCL5,IRF3 and PDL1 were identified as prognostic factors for patients with squamous cell lung cancer(P＜0.05).Conclusion In squamous cell lung cancer tissues,STING is expressed at low levels,while CCL5,IRF3 and PDL1 are ex-pressed at high levels.These findings have significant clinical value in assessing the prognosis of pa-tients with squamous cell lung cancer.关键词
干扰素基因刺激因子/C-C模式趋化因子配体5/干扰素调节因子3/细胞程序性死亡配体1/肺鳞癌/阳性表达/免疫组化/预后评估Key words
stimulator of interferon genes/C-C motif chemokine ligand 5/interferon regula-tory factor 3/programmed death ligand-1/squamous cell lung cancer/positive expression/immuno-histochemistry/prognostic evaluation分类
医药卫生引用本文复制引用
蔡忠福,黄记水,洪文聪,李晓彬,黄燕玲,戴文良,洪友志..干扰素基因刺激因子、C-C模式趋化因子配体5、干扰素调节因子3和细胞程序性死亡配体1在肺鳞癌中的表达及临床意义[J].实用临床医药杂志,2025,29(10):57-62,6.基金项目
福建省泉州市科技计划项目(2022NS020) （2022NS020）
