解放军医学杂志2025，Vol.50Issue(5)：619-631,13.DOI:10.11855/j.issn.0577-7402.1378.2024.1218
慢性肾脏病炎症状态及靶向菌群干预策略的研究进展
Research progress on inflammatory status and targeted microbiota intervention strategies in chronic kidney disease
摘要
Abstract
The inflammatory status in patients with chronic kidney disease(CKD)is closely associated with cardiovascular events,infections,and other complications,and is a powerful indicator for prognosis assessment.The core view of the"gut-kidney axis"theory reveals the relationship among inflammatory state,microbiota dysbiosis,and deterioration of renal function.The microbiota alters the microenvironment through structural changes and metabolites with different properties,subsequently leading to microbiota translocation,inducing inflammatory lesions,and damaging the kidneys.Recent studies have proposed that targeted microbiota intervention strategies such as probiotics,prebiotics,and synbiotics can modulate the microbiota structure,regulate the microenvironment,relieve renal inflammation,and affect the progression of renal disease,representing a potentially promising research direction in the future.This review discusses the characteristics of how intestinal microbiota influence the inflammatory status in CKD,focusing on the research progress of targeted microbiota intervention,aiming to discuss the effectiveness and scientific basis of these strategies,providing a foundation for the treatment of CKD and the expansion of targeted microbiota research,as well as offering references for the clinical application of probiotics,prebiotics,and synbiotics.关键词
慢性肾脏病/炎症/益生菌/益生元/合生元Key words
chronic kidney disease/inflammation/probiotics/prebiotics/synbiotics分类
医药卫生引用本文复制引用
寇少杰,李欣,李粉萍,于小勇,白小林..慢性肾脏病炎症状态及靶向菌群干预策略的研究进展[J].解放军医学杂志,2025,50(5):619-631,13.基金项目
This work was supported by the Shaanxi Province TCM Academic School Inheritance Studio Construction Project([2018]No.40),the 2024 Scientific Research Capacity Improvement Project of Municipal TCM Hospital(SZY-NLTL-2024-18),the Project of Integration of Chinese and Western Medicine of Clinical Medicine Research Center for Infectious Disease of Shaanxi Province(2020LCZX-02),and the 2018 National TCM Administration Regional TCM(Liver Disease)Treatment Center Incubation Unit([2017]No.39) 陕西省中医药管理局-陕西省中医学术流派传承工作室建设项目(陕中医药发[2018]40号) （[2018]No.40）
2024年度市级中医医院科研能力提升项目(SZY-NLTL-2024-18) （SZY-NLTL-2024-18）
陕西省感染性疾病临床医学研究中心中西医结合项目(2020LCZX-02) （2020LCZX-02）
2018年国家中医药管理局区域中医(肝病)诊疗中心培育单位建设项目(国中医药办医政函[2017]39号) （肝病）
