解放军医学杂志2025，Vol.50Issue(5)：632-640,9.DOI:10.11855/j.issn.0577-7402.0467.2024.0913
阿尔茨海默病病理生理机制及其诊断研究进展
Advances in research of pathophysiological mechanisms and diagnosis of Alzheimer's disease
王亚楠 1任凌 1韩伟 2孙彬3
作者信息
- 1. 首都医科大学电力教学医院(国家电网公司北京电力医院)核医学科,北京 100073
- 2. 深圳润铭生物技术有限公司,广东 深圳 518063
- 3. 深圳润铭生物技术有限公司,广东 深圳 518063||华润医药商业医疗器械研究院,北京 100009
- 折叠
摘要
Abstract
Alzheimer's disease(AD),a major cause of dementia,is a common neurodegenerative disease,beginning with memory loss and difficulties with thinking,language and problem-solving skills.Intensification of population aging and the increasing incidence of AD have imposed a heavy burden on healthcare systems.Currently,the main pathological explanation remains the excessive accumulation of β-amyloid plaques,formation of neurofibrillary tangles and neuronal loss,but the true etiology and pathogenesis of AD remain unknown.The advances of research in AD,with respect to genetics,pathophysiological mechanism,imaging diagnosis and laboratory diagnosis,are reviewed in this article,aiming to provide references for relevant research and potential clinical applications.关键词
阿尔茨海默病/认知障碍/影像学诊断/生物标志物Key words
Alzheimer's disease/cognitive impairment/imaging diagnosis/biomarkers分类
临床医学引用本文复制引用
王亚楠,任凌,韩伟,孙彬..阿尔茨海默病病理生理机制及其诊断研究进展[J].解放军医学杂志,2025,50(5):632-640,9.
