实用临床医药杂志2025，Vol.29Issue(10)：116-120,5.DOI:10.7619/jcmp.20245941
大、中卵泡来源卵子占总获卵数比例对体外受精结局的影响
Influence of proportion of large and medium follicle-derived ova in total number of retrieved oocytes on outcome of in vitro fertilization
摘要
Abstract
Objective To investigate the impact of the proportion of ova obtained from large and medium follicles on day of oocyte retrieval on outcomes of in vitro fertilisation(IVF).Methods A total of 120 infertile patients undergoing IVF treatment were selected as study subjects.Single follicle aspiration was performed for oocyte retrieval,and the volume of follicular fluid was measured.Follicu-lar fluid diameter was converted using V=4/3πR3,dividing follicles into large(diameter≥18 mm,V≥3 mL),medium(diameter of＞14 mm to＜18 mm,V of＞1.5 mL to＜3 mL)and small(di-ameter ≤14 mm,V≤1.5 mL)categories.The proportion of oocytes derived from large and medium follicles out of the total retrieved oocytes was calculated and categorised into high-proportion group(proportion of oocytes from large and medium follicles ≥ 71％,n=63)and low-proportion group(proportion＜71％,n=57).Comparisons were made between the two groups regarding follicular maturity,normal fertilisation rate[presence of two pronuclei(2PN)],fertilisation rate,embryo de-velopment and pregnancy outcomes.Results The number of follicles with a diameter＞14 mm on the day of human chorionic gonadotropin(HCG)injection was significantly higher in the high-propor-tion group than that in the low-proportion group(P＜0.05).Rates of mature oocytes(MII),normal fertilisation,fertilisation,high-quality embryo,available blastocyst,frozen embryos and oocyte utilisation rates were significantly higher in the high-proportion group compared to the low-proportion group(P＜0.05).There was no significant difference between the two groups in terms of female age,the number of transferred embryos,rate of transferring high-quality embryos and embryo implantation rate(P＞0.05).Conclusion The actual size of follicles on the day of oocyte retrieval is signifi-cantly correlated with embryo quality and developmental potential.When the proportion of oocytes from large and medium follicles is 71％and above,their maturation rate,fertilisation rate,and em-bryo developmental potential are significantly improved.关键词
体外受精/卵泡/人绒毛膜促性腺激素/胚胎发育/卵泡液体积/受精率/成熟卵母细胞/妊娠结局Key words
in vitro fertilisation/follicle/human chorionic gonadotropin/embryo develop-ment/follicular fluid volume/fertilisation rate/mature oocyte/pregnancy outcome分类
医药卫生引用本文复制引用
唐雪琼,吴晓丹,张静,苏果..大、中卵泡来源卵子占总获卵数比例对体外受精结局的影响[J].实用临床医药杂志,2025,29(10):116-120,5.基金项目
安徽省阜阳市重点研究与开发计划项目(FYZDYF2023LCYX026) （FYZDYF2023LCYX026）
