临床肝胆病杂志2025，Vol.42Issue(5)：975-982,8.DOI:10.12449/JCH250526
组织驻留记忆T细胞在慢性肝病中的调控机制与治疗靶点
The regulatory role of tissue-resident memory T cells in chronic liver diseases and associated therapeutic targets
摘要
Abstract
Tissue-resident memory T cells(TRM cells)are a subset of memory T cells that reside in tissues,exhibit tissue specificity,and do not recirculate.When potential hazards threaten the liver,such as pathogen invasion(bacteria,viruses,etc.)and excessive autoimmune responses,TRM cells are essential as the first line of immune defense,playing an important role in viral hepatitis,autoimmune liver disease,metabolic dysfunction-associated fatty liver disease,liver cirrhosis,and liver transplantation.Here,we present the immunophenotypes of TRM cells in the liver and their surface markers and transcriptional profiles,aiming to clarify the role of TRM cells in chronic liver diseases and explore their potential function as therapeutic targets in immunotherapy.关键词
组织驻留记忆T细胞/肝疾病/免疫疗法Key words
Tissue-resident Memory T Cells/Liver Diseases/Immunotherapy引用本文复制引用
林金,曾煜,田展飞,凡小丽..组织驻留记忆T细胞在慢性肝病中的调控机制与治疗靶点[J].临床肝胆病杂志,2025,42(5):975-982,8.基金项目
国家自然科学基金(82100552) （82100552）
四川大学-达州校市合作专项资金(2022CDDZ-18) National Natural Science Foundation of China(82100552) （2022CDDZ-18）
Sichuan University-Dazhou Cooperation Fundation(2022CDDZ-18) （2022CDDZ-18）
