临床小儿外科杂志2025，Vol.24Issue(5)：436-441,6.DOI:10.3760/cma.j.cn101785-202502050-008
神经源性膀胱患儿泌尿系统感染的危险因素分析
Analysis of risk factors for urinary tract infections in children with neurogenic bladder
摘要
Abstract
Objective To identify the risk factors of urinary tract infection(UTI)in children with neu-rogenic bladder(NB)and provide scientific rationales for its proper clinical management.Methods A total of 169 hospitalized NB children were reviewed at Children's Hospital of Chongqing Medical University from Febru-ary 2015 to February 2023.Based upon the presence or absence of UTI,they were assigned into two groups of UTI(n=90)and non-UTI(n=79).Demographic profiles,clinical features(e.g.,gender,age,gestational age,disease duration,length of hospitalization,history of anorectal surgery,history of sacrococcygeal surgery,history of urinary system surgery,dysuria,frequent micturition & hydronephrosis)and laboratory results(e.g.,routine blood test,routine urine test,liver and kidney function test)were compared between two groups for iden-tifying statistically significant parameters.Multifactorial Logistic regression analysis was performed for variables with significant differences to identify risk factors for UTI.Results Univariate analysis(using P＜0.05 as a screening criterion)revealed that fever,history of urinary tract surgery,leukocyte,blood platelet,hemoglobin,u-rinary clarity,C-reactive protein,leukocyte and blood urea nitrogen(BUN)were associated with UTI in NB children.Excluding multicollinearity,multivariate Logistic regression analysis revealed that leukocyte,BUN,his-tory of urinary tract surgery and hydronephrosis were the risk factors for UTI in NB children(P＜0.05).A-mong them,the risk of UTI in children with elevated leukocyte was 13.367 folds higher than that in normal group(OR=13.367,95％CI:3.732-47.878);the risk of UTI in children with elevated BUN was 1.102 folds higher than that in normal group(OR=1.102,95％CI:1.019-1.193);children with a history of uri-nary tract surgery had a 2.118 folds higher risk(OR=2.118,95％CI:0.999-4.490);the risk for those with hydronephrosis was 4.010 folds higher(OR=4.010,95％CI:1.857-8.658).Conclusions Leuko-cyte,BUN,history of urinary tract surgery and hydronephrosis are important risk factors for UTI in NB children and these parameters should be closely monitored in clinical practices.关键词
膀胱,神经原性/泌尿道感染/危险因素/儿童Key words
Urinary Bladder,Neurogenic/Urinary Tract Infections/Risk Factors/Child引用本文复制引用
杨舒涵,刘星,吴盛德,魏光辉,喻先海,崔孔孔,刘秩源,陈静,余成军,蔡淼,张德迎,华燚..神经源性膀胱患儿泌尿系统感染的危险因素分析[J].临床小儿外科杂志,2025,24(5):436-441,6.基金项目
重庆市自然科学基金创新发展联合基金(市教委项目)(CSTB2024NSCQ-LZX0054) Chongqing Medical Scientific Research Grant(Joint Project of Chongqing Municipal Health Commission and Science & Technology Bureau)(CSTB2024NSCQ-LZX0054) （市教委项目）
