临床小儿外科杂志2025，Vol.24Issue(5)：495-500,6.DOI:10.3760/cma.j.cn101785-202405069-019
脂氧素A4的生物学作用及其治疗脊髓缺血再灌注损伤的研究进展
Research advances in mechanism and intervention strategies of lipoxygen-4 in spinal cord ischemia-reperfusion injury
摘要
Abstract
Spinal cord ischemia-reperfusion injury(SCI/R)is a serious neurological insult with a com-plex pathogenesis and a difficult intervention.As a lipid molecule with multiple regulatory effects,lipoxin A4(LXA4)plays an important role in various diseases.Recent studies have revealed that LXA4 plays an important role in SCI/R and it may serve as a potential therapeutic target.This review focused upon the biological charac-teristics and synthetic metabolic pathways of LXA4.And LXA4 exerts its biological effects through activating G protein coupled receptors,regulating neuroinflammatory responses,promoting tissue repair and protecting neuro-nal function.And based upon this,the mechanism of action and intervention strategies of LXA4 in SCI/R were summarized,including relieving leukocyte infiltration,arresting cell apoptosis and suppressing the release of in-flammatory factors through drug and gene pathways,blunting the injury of SCI/R to nervous system and promo-ting the repair and regeneration of tissue injury.In the future,researchers shall further explore the mechanism of action of LXA4,seek more effective intervention strategies and provide more new thoughts for clinical treatment of SCI/R.关键词
脊髓缺血再灌注损伤/脂氧素A4/治疗/儿童Key words
Spinal Cord Ischemia-Reperfusion Injury/Lipoxygenase A4/Therapy/Child引用本文复制引用
檀盛,刘晏东,张彦军,王鹏,郭铁峰..脂氧素A4的生物学作用及其治疗脊髓缺血再灌注损伤的研究进展[J].临床小儿外科杂志,2025,24(5):495-500,6.基金项目
国家自然科学基金(82060879) （82060879）
甘肃省临床优势专科骨科建设项目(2024) National Natural Science Foundation of China(82060879) （2024）
Gansu Province Clinical Ad-vantage Specialized Orthopedic Construction Project(2024) （2024）
