临床输血与检验2025，Vol.27Issue(3)：291-299,9.DOI:10.3969/j.issn.1671-2587.2025.03.002
中国人群红细胞意外抗体阳性率调查及特异性抗体分布特征
Investigate the Positive Rate of Unexpected Red Cell Antibodies and Distribution Characteristics of Specific Antibodies in the Chinese Population
摘要
Abstract
Objective This survey aims to comprehensively and systematically analyze the positive rate of unexpected red cell antibodies and the distribution characteristics of specific antibodies in the Chinese population.This study aims to provide data support for screening unexpected antibodies and for determining the spectrum of cell antigen composition in China.Methods Research literature on unexpected antibodies in hospitalized patients and blood donors across 31 provinces and municipalities in China was searched in PubMed,CNKI,Wanfang Data,and other authoritative databases from 1981 to December 2023.The literature was screened according to inclusion and exclusion criteria,data extraction was performed,and a quality assessment was conducted.Results The positive rate of unexpected red cell antibodies in hospitalized patients was 0.47%.The rate in blood donors was 0.10%.The rate in hospitalized mothers was 0.71%.The rate in blood transfusion patients was 1.22%,and the rate in pregnant women was 0.91%.The positive rate in blood transfusion/pregnancy was 1.15%.The proportion of specific antibodies in hospitalized patients is in the following order:Rh＞MNS＞Lewis＞Kidd＞Duffy＞Xg＞ABO subtype＞I＞Diego＞P＞Kell＞Lutheran＞H;the proportion of specific antibodies in blood donors is in the following order:MNS＞Rh＞Lewis＞P＞ABO subtype＞I＞Kell＞Kidd＞Diego＞Duffy＞Lutheran＞H;the proportion of specific antibodies in pregnant and postpartum women is in the following order:Rh＞MNS＞Lewis＞Kidd＞P＞H＞Duffy＞I＞Diego.The composition proportion of specific antibodies in hospitalized patients is in the following order:anti-E＞anti-M＞anti-D＞anti-Ec＞anti-Lea＞anti-C＞anti-c＞anti-Jka＞anti-Ce＞anti-Leb,the composition proportion of specific antibodies in blood donors is in the following order:anti-M＞anti-E＞anti-P1＞anti-D＞anti-Lea＞anti-Leb＞anti-C＞anti-N＞anti-I＞anti-A1;the composition proportion of specific antibodies in pregnant and postpartum women is in the following order:anti-E＞anti-M＞anti-D＞anti-C＞anti-Lea＞anti-Ec＞anti-EC＞anti-P1.Conclusion The positive rate of unexpected antibodies in hospitalized patients in China is significantly higher than that in blood donors,and the distribution characteristics of specific antibodies vary among different populations and regions.关键词
红细胞/红细胞意外抗体/特异性抗体/血型Key words
Red cell/Unexpected red cell antibodies/Specific antibodies/Blood groups分类
临床医学引用本文复制引用
宋奥微,杨江存,孙杨,王文文,田芬芳,邢莉莉,牛佳萌,常婧妍,杨颖群,马婷,王文华..中国人群红细胞意外抗体阳性率调查及特异性抗体分布特征[J].临床输血与检验,2025,27(3):291-299,9.基金项目
本课题受陕西省科技厅科技成果转移与推广计划-获奖成果转化项目(No.2019CGHJ-09),陕西省人民医院领军人才基金项目(No.2021LJ-14)资助 （No.2019CGHJ-09）
