现代畜牧兽医Issue(5)：44-47,4.DOI:10.20154/j.cnki.issn1672-9692.2025.05.009
1例比格犬发育不全的病理学诊断与实验动物管理建议
Pathological diagnosis of one case of hypoplasia in Beagle dog and management suggestions for experimental animals
陈舒怀 1吴晓星 2吴波 1孟雪 1张劲松1
作者信息
- 1. 浙江省食品药品检验研究院 全省生物医药接触材料重点实验室,浙江 杭州 310052
- 2. 浙江大学医学院附属第二医院小动物实验中心,浙江 杭州 310009
- 折叠
摘要
Abstract
Hypoplasia is a common hereditary disease in dogs.Its clinical manifestations are extreme emaciation and fat depletion in dogs.Histological examination shows multiple organ atrophy and hypoplasia.The case in the article was a male Beagle purchased during the quarantine period.It was found that its nutritional status was poor during quarantine.After a two-month breeding and observation period,there was no improvement,so it was culled.Dissection revealed that the dog had abnormal development of multiple organs.Clinical hematological examination showed that it was anemic and malnourished.Histopathological examination revealed atrophy of the thyroid gland,thymus,spleen and reproductive system,accompanied by cystic mucinous hyperplasia of the gallbladder.The comprehensive diagnosis was multiple organ atrophy or hypoplasia,suspected to be caused by congenital genetic factors,and it could not recover in the laboratory breeding environment.This case provides certain references for the quarantine standards of experimental animals,suggesting that a developmental assessment mechanism needs to be established in the animal screening stage of repeated drug administration toxicity tests.By systematically excluding individuals with incomplete development,the risk of deviation in test data can be effectively reduced.关键词
发育不全/发育不良/比格犬/实验动物管理Key words
Dysgenesis/Dysplasia/Beagle dog/Laboratory animal management分类
农业科技引用本文复制引用
陈舒怀,吴晓星,吴波,孟雪,张劲松..1例比格犬发育不全的病理学诊断与实验动物管理建议[J].现代畜牧兽医,2025,(5):44-47,4.
