南京中医药大学学报2025，Vol.41Issue(6)：813-821,9.DOI:10.14148/j.issn.1672-0482.2025.0813
长胜七中木脂素类化学成分研究
Study on the Chemical Components of Lignans from the Root Bark of Schisandra Sphenanthera
摘要
Abstract
OBJECTIVE To study the chemical constituents in the root bark of Schisandra sphenanthera and their cytotoxic activ-ities.METHODS The compounds were isolated and purified by silica,Sephadex LH-20 and semi preparative-HPLC and the chem-ical structures were identified by 1 H-NMR,13 C-NMR and MS data analysis.The cytotoxic activities of the compounds were deter-mined by MTT method.RESULTS Twenty lignans were isolated and deduced as:Matairesinol(1),2-Hydroxy-2-(3′,4′-di-hydroxyphenyl)methyl-3-(3″,4″-dimethoxyphenyl)methyl-gamma-butyrolactone(2),(+)-Nortrachelogenin(3),2-Hydroxy-2-(4′-O-β-D-glucopyranosyl-3′-hydroxyphenyl)methyl-3-(3″,4″-dimethoxyphenyl)methyl-γ-butyrolactone(4),Nortracheloside(5),Burselignan(6),(+)-Cycloolivil(7),5-Methoxy-(+)-isolariciresinol(8),(-)-Isolariciresinol 3α-O-β-D-glucopyranoside(9),(+)-9-O-β-D-Glucopyranosyl lyoniresinol(10),(-)-Secoisolariciresinol(11),Licarin A(12),Cedrusin(13),Mataires-inol 4′-O-β-D-glucopyranoside(14),Pregomisin(15),Meso-dihydroguaiaretic acid(16),7S,8R-Erythro-4,9,9′-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-7-O-β-D-glucopyranoside(17),Gomisin M2(18),Gomisin M3(19),Pinoresinol(20).Com-pounds 1-3,12,15,16,18 and 19 showed cytotoxic activity against A549,HCT116 and SW620 cell lines with IC50 values ranging from 1.4 to 22.9 μmol·L-1.CONCLUSION Compounds 1-4,6-12,14,17-19 are isolated from the plant for the first time,com-pounds 1-3,12,15,16,18 and 19 exhibit cytotoxic activities.关键词
长胜七/华中五味子/化学成分/木脂素/细胞毒活性Key words
root bark of Schisandra sphenanthera/Schisandra sphenanthera/chemical components/lignans/cytotoxity分类
医药卫生引用本文复制引用
王雨轩,刘媛媛,张玉莹,黄仕其,李玉泽,邓翀,宋小妹,王薇,张东东..长胜七中木脂素类化学成分研究[J].南京中医药大学学报,2025,41(6):813-821,9.基金项目
国家自然科学基金面上项目(82174111) （82174111）
陕西中医药大学创新团队项目(2023-CXTD-05) （2023-CXTD-05）
