临床输血与检验2025，Vol.27Issue(3)：412-422,11.DOI:10.3969/j.issn.1671-2587.2025.03.021
tsRNAs的生成及生物学功能研究进展
Advances in the Generation and Biological Function of tsRNAs
摘要
Abstract
With the development of high-throughput sequencing technology and the advancement of bioinformatics technology,transfer RNA(tRNA)derived small RNAs(tsRNAs)have received widespread attention as a novel type of non-coding small RNAs.Based on the differences in nuclease cleavage sites on tRNAs,tsRNAs can be classified into four major categories:tRNA-derived fragments(tRFs),tRF-1,tRNA-derived stress-inducible small RNAs(tiRNAs)and other unclassified tsRNAs,each of which has a specific subcellular localization.Recent studies have revealed that tRNAs play important roles in embryonic development,cell fate,immune regulation and the development of many human diseases.Therefore,this paper systematically reviews the biological origin,classification of tsRNAs and the biological functions of tsRNAs,including gene expression regulation,translational regulation,epigenetic regulation,reverse transcriptional regulation and neonatal RNA silencing,and explores the feasibility of tsRNAs as diagnostic markers and therapeutic targets for diseases.关键词
tsRNA/非编码小RNA/tRF/tiRNA/生物学功能Key words
tsRNA/small non-coding RNA/tRF/tiRNA/biological function分类
生物学引用本文复制引用
刘悦,刘瑶,万九超,管圣文,赵攀..tsRNAs的生成及生物学功能研究进展[J].临床输血与检验,2025,27(3):412-422,11.基金项目
本课题受四川省自然科学基金青年项目(No.2022NSFSC1416)资助 （No.2022NSFSC1416）
