南京中医药大学学报2025，Vol.41Issue(6)：832-837,6.DOI:10.14148/j.issn.1672-0482.2025.0832
养阴益肺汤治疗气阴两虚型2型糖尿病伴角蛋白19片段升高患者的临床研究
Clinical Study on Yangyin Yifei Decoction in Treating Type 2 Diabetes Mellitus Patients with Qi-Yin Deficiency and Elevated Keratin 19 Fragment
摘要
Abstract
OBJECTIVE To observe the clinical efficacy of Yangyin Yifei Decoction in treating type 2 diabetes mellitus(T2DM)patients with of qi-yin deficiency and elevated serum keratin 19 fragment(Cyfra21-1).METHODS Sixty patients with T2DM of qi-yin deficiency type and elevated serum Cyfra21-1 who met the inclusion criteria were selected and randomly divided into an observation group and a control group,30 cases in each group.The control group was given oral hypoglycemic treatment with metformin hydrochlo-ride sustained-release tablets and dapagliflozin tablets,and the observation group was given Yangyin Yifei Decoction on the basis of the treatment of the control group.The treatment course of both groups was 12 weeks.Before and after treatment,the changes of traditional Chinese medicine(TCM)syndrome scores,fasting blood glucose(FBG)and 2-hour postprandial glucose(2 h PG),glycosylated he-moglobin(HbAlc),serum Cyfra21-1 and Cyfra21-1 specific T cell response,triglycerides(TG),total cholesterol(TC),alanine ami-notransferase(ALT),aspartate aminotransferase(AST),urea(UR),and creatinine(CREA)were observed in the two groups.RE-SULTS After treatment,FBG,2 h PG,HbAlc,and TCM syndrome scores of the two groups of patients decreased significantly(P<0.05,P<0.01),and the observation group was better than the control group(P<0.05,P<0.01);TG and TC in the observation group were significantly reduced(P<0.01),serum Cyfra21-1 was significantly decreased(P<0.01),and Cyfra21-1-specific T cells in PBMCs were significantly increased(P<0.01),which was better than the control group(P<0.01);there was no significant change in liver and kidney function in the two groups.CONCLUSION Yangyin Yifei Decoction combined with basic hypoglycemic regimen can significantly improve blood glucose and lipid metabolism in T2DM patients with qi-yin deficiency and elevated serum Cyfra21-1,enhance the function of Cyfra21-1-specific T cells,and improve the body's immunity,with high safety.关键词
2型糖尿病/气阴两虚证/养阴益肺汤/血清Cyfra21-1/Cyfra21-1特异性T细胞Key words
type 2 diabetes mellitus/qi-yin deficiency syndrome/Yangyin Yifei Decoction/serum Cyfra21-1/Cyfra21-1 specific T cells分类
医药卫生引用本文复制引用
朱苏平,方朝晖..养阴益肺汤治疗气阴两虚型2型糖尿病伴角蛋白19片段升高患者的临床研究[J].南京中医药大学学报,2025,41(6):832-837,6.基金项目
国家自然科学基金面上项目(81774286,81603574) （81774286,81603574）
方朝晖安徽省名中医工作室建设项目(2019-8-515) （2019-8-515）
