世界科学技术-中医药现代化2025，Vol.27Issue(5)：1287-1296,10.DOI:10.11842/wst.20240731002
中国早发性卵巢功能不全生存质量量表的研制
Development of the Chinese Premature Ovarian Insufficiency Quality of Life Scale
摘要
Abstract
Objective To develop a quality of life(QoL)scale for Premature Ovarian Insufficiency(POI)with high reliability and validity in accordance with China's national conditions.Methods The theoretical framework of the scale was constructed under the guidance of traditional Chinese medicine theory with reference to the development method of the QoL scale.Literature analysis method,medical record review method,patient interview method,Delphi expert consultation method and clinical investigation were used to establish,improve and screen the scale items to form the final scale,and the characteristics and differentiation in terms of reliability and validity and feasibility of the final scale were evaluated.Results After screening the entries by the Delphi method and clinical surveys,the Chinese Premature Ovarian Insufficiency Quality of Life Scale was formed,which included three domains of physiology,psychology,and society,and eleven aspects such as menstruation,fertility,and physical symptoms,with 30 entries and two overall evaluations.The Cronbach's coefficient of this scale was 0.910,the fold-half coefficient was 0.956,and the re-test correlation coefficient was 0.868,which showed good internal consistency,fold-half and re-test reliabilities;the scale extracted 9 factors with characteristic root>1,and the cumulative variance contribution rate was 71.063%,the comparative fit index was 0.959,and the goodness-of-fit index was 0.919,and the degree of correlation was tested has showed that the content validity,structural validity and calibration correlation validity were good;the difference in the total scores of the scale between patients with POI and the healthy population was statistically significant,and the scale had a good degree of differentiation.Conclusion As confirmed by this study,the Chinese Premature Ovarian Insufficiency Quality of Life Scale has good reliability,validity,differentiation and feasibility,and can be used as a tool for evaluating the quality of life of POI patients in China as well as enriching the efficacy evaluation system of TCM in treating POI,and it is suitable for clinical popularization and application.关键词
早发性卵巢功能不全/生存质量量表/研制/考评Key words
Premature ovarian insufficiency/Quality of life scale/Development/Evaluation分类
医药卫生引用本文复制引用
郑允玲,邹宇馨,李堉成,陈卓婷,黄柳倩,潘欣仪,朱玲..中国早发性卵巢功能不全生存质量量表的研制[J].世界科学技术-中医药现代化,2025,27(5):1287-1296,10.基金项目
国家自然科学基金委员会面上项目(82174418):补肾填精法调控Notch1/Nrf2信号通路改善卵巢生殖干细胞组蛋白乙酰化修饰治疗早发性卵巢功能不全的研究,负责人:朱玲 （82174418）
广州市科技计划重点研发计划(2024B03J1259):补肾填精法调控Notch1/NF-κB信号通路改善卵巢衰老生殖干细胞免疫微环境失衡的作用及机制研究,负责人:朱玲 （2024B03J1259）
国家中医药管理局(国中医药人教函[2022]5号):罗颂平全国名中医工作室,负责人:朱玲. （国中医药人教函[2022]5号）
