摘要
Abstract
Objective To explore the preventive effect of different doses of dexmedetomidine on postoperative nausea and vomiting and its impact on analgesia in elective ophthalmic lacrimal duct surgery.Methods Eighty patients,aged 20-59 years old,of American So-ciety of Anesthesiologists(ASA)Physical Status classification Ⅰ or Ⅱ,who underwent general anesthesia for ophthalmic lacrimal duct sur-gery at Aier Eye Hospital Affiliated to Wuhan University from August 2023 to August 2024 were selected as the research subjects.Accord-ing to the drug dose,they were divided into three groups:0.2 μg/kg dexmedetomidine group(group A,n=28),0.4 μg/kg dexmedeto-midine group(group B,n=26),and 0.8 μg/kg dexmedetomidine group(group C,n=26).All three groups were diluted to 50 mL with 0.9％sodium chloride,and the infusion time was 10 minutes before general anesthesia induction.Results None of the patients in three groups had grade Ⅳ nausea or vomiting.The visual analogue scale(VAS)scores of three groups at 24 h after surgery were significantly lower than those at 1 h and 12 h after surgery,and the differences were statistically significant(P＜0.05).The total incidence of adverse reac-tions in group A and group B were lower than that in group C,and the difference was statistically significant(P＜0.05).Compared with group A and group B,the incidence of adverse reactions such as bradycardia,dizziness,and excessive sedation in group C was significantly higher,and the difference was statistically significant(P＜0.05).Conclusion The administration of 0.4 μg/kg of dexmedetomidine can more effectively prevent adverse reactions such as nausea and vomiting in patients undergoing general anesthesia for ophthalmic lacrimal duct surgery.Excessive large doses of dexmedetomidine may increase the incidence of postoperative adverse reactions in patients,and the drug dosage needs to be determined according to the clinical situation of patients.关键词
眼科泪道手术/右美托咪定/术后恶心呕吐/术后镇痛Key words
ophthalmic lacrimal passage surgery/dexmedetomidine/postoperative nausea and vomiting/postoperative analgesia
