实用医学杂志2025，Vol.41Issue(11)：1718-1723,6.DOI:10.3969/j.issn.1006-5725.2025.11.016
氨酚羟考酮联合局部放疗对老年恶性肿瘤骨转移癌痛患者血清细胞因子的影响
Influence of oxycodone-acetaminophen combined with local radiotherapy on serum cytokines in elderly pa-tients with malignant tumor bone metastasis complicated with cancer pain
摘要
Abstract
Objective To investigate the influence of combination of oxycodone-acetaminophen and local radiotherapy on serum cytokines in elderly patients with malignant tumor bone metastasis and cancer pain.Methods Eighty elderly patients with malignant tumor bone metastasis and cancer pain admitted to Huainan Xinhua Medical Group Xinhua Hospital from January 2020 to April 2024 were divided into control group(40 cases)and observa-tion group(40 cases)according to the order of admission.The control group received codeine combined with local radiotherapy,whereas the observation group was treated with oxycodone-acetaminophen combined with local radio-therapy.Pain relief(assessed using visual analogue scale(VAS)),daily fulminant pain occurrence frequency and occurrence of adverse reactions during treatment as well as serum cytokines[substance P(SP),prostaglandinE2(PGE2),interleukin-6(IL-6)],sleep quality(assessed using Pittsburgh sleep quality index(PSQI))and quality of life[assessed using functional assessment of cancer therapy-general(FACT-G)]before and after treatment were compared between the two groups..Results The pain relief effect in the observation group was better(P<0.05),and the daily occurrence frequency of fulminant pain was less than that in the control group(P<0.05).After treat-ment,serum levels of SP,PGE2 and IL-6 in the observation group were lower compared to those in the control group(P<0.05).The total incidence rate of bone-related events during treatment was not significantly different between the two groups(P>0.05),and the total incidence rate of adverse reactions was lower in the observation group compared to those in the control group(P<0.05).The PSQI score in the observation group after treatment was lower(P<0.05)while the scores of physiology and emotion of FACT-G were higher compared to those in the control group(P<0.05).Conclusion Oxycodone-acetaminophen combined with local radiotherapy can down-regulate the levels of serum SP,PGE2 and IL-6,relieve the pain,and improve the sleep quality and quality of life in elderly patients with malignant tumor bone metastasis complicated with cancer pain.关键词
恶性肿瘤/骨转移/癌痛/老年/氨酚羟考酮/放疗/前列腺素E2/白细胞介素-6Key words
malignant tumor/bone metastasis/cancer pain/elderly/oxycodone-acetaminophen/radiotherapy/prostaglandinE2/interleukin-6分类
医药卫生引用本文复制引用
石明宏,刘占伟,朱洋,夏丽丽,程刚,陆友国..氨酚羟考酮联合局部放疗对老年恶性肿瘤骨转移癌痛患者血清细胞因子的影响[J].实用医学杂志,2025,41(11):1718-1723,6.基金项目
安徽省卫生健康科研项目(编号:AHWJ2023BAa20129) （编号:AHWJ2023BAa20129）
