实用医学杂志2025，Vol.41Issue(11)：1751-1759,9.DOI:10.3969/j.issn.1006-5725.2025.11.021
肿瘤细胞迁移关键调节因子Rho GTPase激活蛋白研究进展
Research progress of Rho GTPase activating protein for regulator of tumor cell migration
摘要
Abstract
Rho GTPase-activating proteins(ARHGAP)constitute a family of multifunctional regulatory proteins that negatively regulate Rho family GTPases(e.g.,RhoA,Rac1,Cdc42)by accelerating the hydrolysis bound to these enzymes.Members of this family are extensively involved in crucial biological processes such as cellular signal transduction,adhesion,and dynamic reorganization of cytoskeleton,while also playing significant roles in tumor progression.ARHGAP expression and function vary across cancer types,with identical molecule exhibiting divergent expression levels and biological effects in various malignancies.The regulatory effects of ARH-GAP family members on tumor cell migration are closely associated with their unique structural domain characteris-tics and are modulated by multiple signaling pathways.This paper comprehensively analyzes and summarizes exist-ing research to explore the roles and mechanisms of ARHGAP family members in tumor cell migration,aiming to identify potential biomarkers and therapeutic targets in cancer management and prevention.关键词
Rho GTPase激活蛋白/Rho家族GTP酶/肿瘤/迁移/信号通路Key words
ARHGAP/Rho GTPase/tumor/migration/signaling pathway分类
医药卫生引用本文复制引用
陈诗涵,季湧,朱伟..肿瘤细胞迁移关键调节因子Rho GTPase激活蛋白研究进展[J].实用医学杂志,2025,41(11):1751-1759,9.基金项目
国家自然科学基金资助项目(编号:81972313) （编号:81972313）
江苏省卫生健康委员会医学科研资助项目(编号:X373) （编号:X373）
