同位素2025，Vol.38Issue(3)：247-252,6.DOI:10.7538/tws.2024.youxian.072
碳[11C]胆碱注射液离子色谱鉴别和放化纯度测定方法的建立
Establishment of Ion Chromatography Method for Identification and Determination of the Radiochemical Purity of[11C]Choline Injection
摘要
Abstract
[11C]choline is a normal tracer using for PET/CT,identification of[11C]choline and analysis its radiochemical purity are important to guarantee the validity and safety of tracer.This study aims to establish a new,rapid and effective performance method for identification of[11C]choline and analysis of the radiochemical purity in the products.The chromatographic method of radio-IC-flow-count were performed using a Metrosep C 6-150/4.0 column with mobile phase of 6 mmol/L HNO3+5%acetone aqueous solution,flow rate was 0.9 mL/min.The choline chloride and Na+retention time were 8.94 min and 3.04 min,[11C]choline were 9.25 min.The established separating method using IC-flow-count showed good efficiency,The linear range of calibration curves was 10-100 mg·L-1 for choline chloride,with the recovery rate ranged from 98.9%to 102.1%and the intrabatch and innerbatch variations of<7.8%.The radio-IC-flow-count method is simple,valid and quick for the identification of[11C]choline and analysis of radiochemical purity.关键词
碳[11C]胆碱/离子色谱/放化纯度/鉴别Key words
[11C]choline injection/ion chromatography/radiochemical purity/identification分类
核科学引用本文复制引用
张国晋,何山震..碳[11C]胆碱注射液离子色谱鉴别和放化纯度测定方法的建立[J].同位素,2025,38(3):247-252,6.基金项目
广州市基础研究计划基础与应用基础研究项目(202102080400) （202102080400）
广东省人民医院国家自然科学基金配套启动经费(820707413、8217071425和2237070006) （820707413、8217071425和2237070006）
