同位素2025，Vol.38Issue(3)：304-312,9.DOI:10.7538/tws.2024.youxian.085
钪-47制备及其标记药物研究进展
Preparation Techology and Labeled Compounds of Scandium-47:Research Progress
摘要
Abstract
Medical isotopes are the substantial basis of the diagnostic and therapeutic nuclear medicine.There are irreplaceable advantages for utilizing the nuclear medical technology to diagnose and treat the malignant tumors,cardiovascular and cerebrovascular diseases,neurodegenerative diseases and other major diseases.Scandium-47(47Sc)is a novel medical isotope proposed in recent years,its moderate radiation energy and favorable coordination chemical properties make it easy to bind with biological targeting molecules to prepare drugs for cancer treatment.It can also form a diagnostic and therapeutic isotope pair with its isotopes 44Sc and 43Sc,making it a true theranostics isotope with broad application potential.This article reviews the irradiation preparation technology and separation extraction techniques of 47Sc based on reactors or accelerators,briefly introduces the current status of research on 47Sc-labeled drugs,and analyzes the development trends and application prospects of 47Sc in the future.关键词
钪-47/同位素分离技术/放射性药物/靶向治疗Key words
Scandium-47/isotope separation technique/radiopharmaceutical/targeted therapy分类
能源科技引用本文复制引用
李波,廖瑜浩,胡映江,陈云明,罗宁,张劲松..钪-47制备及其标记药物研究进展[J].同位素,2025,38(3):304-312,9.基金项目
四川省科技计划资助(2023YFS0007) （2023YFS0007）
