武警医学2025，Vol.36Issue(5)：384-387,4.
富血小板血浆对皮肤细胞增殖和分化的影响及其作用机制
Effects and mechanism of platelet-rich plasma on the proliferation and differentiation of skin cells
摘要
Abstract
Objective To explore the effects of platelet-rich plasma(PRP)on the proliferation and differentiation of skin cells and its mechanisms of action.Methods Human dermal fibroblasts(HDFs)and human epidermal keratinocytes(HEKs)were cultured in vitro and subjected to varying concentrations of PRP at different concentrations.Cell counting kit-8(CCK-8),immunofluo-rescence staining and enzyme-linked immunosorbent assay(ELISA)techniques were utilized to evaluate cell proliferation,differentia-tion,and the expression of associated growth factors,and the effects of different concentrations of PRP on HDFs and HEKs were sys-tematically evaluated.Results PRP significantly enhanced the proliferation rates of HDFs and HEKs,facilitated cell differentiation,and upregulated the expression of growth factors such as platelet derived growth factor(PDGF),epidermal growth factor(EGF),and fi-broblast growth factor(FGF),and the differences were statistically significant(P<0.05).Conclusions PRP can increase the expres-sion level of growth factors in promoting the proliferation and differentiation of skin cells.关键词
富血小板血浆/皮肤细胞/增殖/分化/生长因子Key words
platelet-rich plasma/skin cells/proliferation/differentiation/growth factors分类
医药卫生引用本文复制引用
郭晓今,马晨凯,舒心,潘纪春..富血小板血浆对皮肤细胞增殖和分化的影响及其作用机制[J].武警医学,2025,36(5):384-387,4.基金项目
解放军总医院第三医学中心学科创新发展专项基金 （）
