摘要
Abstract
Objective To analyze the effects of ultrasound-guided transverse abdominis plane block(TAPB)combined with continuous infusion of cyclopofol on inflammatory factors and TAU-181 in patients after radical gastrectomy for gastric cancer(GC).Methods A total of 84 patients who underwent radical gastrectomy for GC in Jiangxi Provincial Corps Hospital of Chinese People's Armed Police Force from October 2022 to October 2024 were selected and divided into a control group and a combination group,with 42 cases in each group.The control group was given ultrasound-guided TAPB,while the combined group received ultrasound-guided TAPB combined with cyclopofol.The level of postoperative indicators was recorded,the sedation and pain scores at different time points,the MMSE scale,the expression levels of TNF-α,IL-6,CRP,and TAU-181 were detected,and the adverse reactions of both groups were re-corded.Results The operation time of the combined group(138.15±20.27 min)was shorter than that of the control group(185.56±26.64 min).The intraoperative blood loss was(109.44±11.40 ml),which was less than that of the control group(153.13±15.95 ml).The time of the first use of analgesic drugs after the operation(30.22±7.55 min)was later than that of the con-trol group[(26.21±7.42)min],and the differences were statistically significant(P<0.05).At 6h,12h and 48h after surgery,the Ramsay sedation score of the combined group was higher than that of the control group,and the VAS score was lower than that of the control group.The differences were statistically significant(P<0.05).At time points of T1,T2,T3 and T4,compared with the control group,the MMSE scores in the combined group increased,and the differences were statistically significant(P<0.05).After 7 days,compared with the control group,the proteins of TNF-α,IL-6,CRP and TAU-181 in the combined group decreased and the differ ences were statistically significant(P<0.05).Conclusion For patients after radical gastrectomy for GC,ultrasound-guided TAPB combined with cyclopofol can increase the degree of seda-tion,reduce pain,improve cognitive function,alleviate inflamma-tory response,regulate the expression of TAU-181 protein,reduce the incidence of postoperative complications,and be more conducive to postoperative recovery.关键词
超声引导/腹横肌平面阻滞/环泊酚/胃癌根治术/炎症因子/人磷酸化TAU-181蛋白Key words
ultrasound guidance/transverse abdominis plane block/cyclopanol/radical gastric cancer/inflammatory factors/human phosphorylated TAU-181 protein分类
医药卫生
