武警医学2025，Vol.36Issue(5)：426-434,9.
成人代谢健康型肥胖与炎症因子关系的Meta分析
Meta-analysis on the association between adult metabolically healthy obesity and inflam-matory factors
摘要
Abstract
Objective To systematically evaluate the association between adult metabolically healthy obesity(MHO)and va-rious inflammatory factors,and to provide a basis for the early serological warning of obesity inflammation.Methods Cross-sectional studies on the association between MHO and inflammatory factors from CNKI,Wanfang,VIP,CBM,PubMed,Web of Science,Em-base and Cochrane Library were retrieved,with the publication time limit set from inception to August 3,2024.The quality of the liter-ature was evaluated using the bias risk assessment form from AHRQ.Meta analysis was performed using RevMan 5.4 and a funnel plot was drawn.Subgroup analysis was conducted based on such aspects as the definitions of obesity and MS definitions(MS),regions and specific types of inflammatory factors.Results A total of 21 cross-sectional studies from 12 countries were included,involving 23308 re-search subjects,including 5842 MHO people and 17466 MHNO people.Meta-analysis results showed that white blood cell count(WB-CC)(95%CI:0.02～0.18,P=0.01),c-reactive protein(CRP)(95%CI:0.53～0.82,P<0.00001),adiponectin(APN)(95%CI:-1.43～-0.43,P=0.0003),leptin(LEP)(9 5%C I:1.39～0.43,P<0.00001),and interleukin(IL)-6(95%CI:0.1 3～1.29,P=0.02)were all correlated with adult metabolic health obesity.Analysis of each subgroup suggested that hypersensitive C-reactive protein(ha-CRP)showed a more significant difference than CRP in the two groups of people(SMD=0.73,95%CI:0.59～0.88).In the TNF-α and IL-6 groups,BMI≥25 kg/m2 was more significant than 30 kg/m2 as the diagnostic criterion for obesity between the two groups(SMD=1.14,95%CI:0.71～1.56),(SMD=2.15,95%C I:1.6 5～2.64).MHO people in North America had higher levels of APN and LEP than those in other regions(SMD=-3.16,95%CI:-4.19～-2.13),(SMD=8.46,9 5%CI:6.25,10.67);The distribution sym-metry of the funnel plot in this study was relatively good,indicating no significant publication bias.Conclusions Adult MHO is significantly correlated with inflammatory factors such as WBCC,CRP,APN,LEP,and IL-6.The detection of serum inflammatory factors in obese individuals is of great significance for early warning of obe-sity-related diseases.关键词
代谢健康型肥胖/炎症因子/早期预警/Meta分析Key words
metabolically healthy obesity/inflammatory factor/early warning/meta analysis分类
临床医学引用本文复制引用
吴梓敬,李纪新,邱林杰,任燕,邹姹姹,李美洁,栗文婕,张晋..成人代谢健康型肥胖与炎症因子关系的Meta分析[J].武警医学,2025,36(5):426-434,9.基金项目
中国中医科学院西苑医院具有知识产权的医疗机构制剂和中药新药的研究与转化专项(XYZX0301-16) （XYZX0301-16）
北京中医药薪火传承"3+3"工程项目(2023-SZ-A-5) （2023-SZ-A-5）
中国中医科学院科技创新工程(CI2021A03005) （CI2021A03005）
