刑事技术2025，Vol.50Issue(3)：243-251,9.DOI:10.16467/j.1008-3650.2024.0040
1H-qNMR用于海洛因、可卡因及常见掺杂物定量分析的方法研究
1H-qNMR for the Quantification of Heroin,Cocaine and Common Adulterants
摘要
Abstract
For the first time,a general 1H-quantitative nuclear magnetic resonance spectrometry(1H-qNMR)method for the simultaneous quantification of heroin hydrochloride,cocaine,cocaine hydrochloride,and 7 adulterants was established after the discussion of some key quantitative parameters.According to the solubility and stability of heroin hydrochloride,cocaine,and cocaine hydrochloride in different deuterated solvents,and the spectra comparison of seized samples and reference materials,dimethylsulfoxide-d6 was selected as the solvent,and 1,3,5-trimethoxybenzene was selected as the internal standard.The signals at δH 6.09 ppm for internal standard 1,3,5-trimethoxybenzene;at δH 6.87,6.71,2.24 ppm for heroin hydrochloride;at δH 7.90,7.64,5.12,3.61 ppm for cocaine;and at δH 7.88,5.49,2.79 ppm for cocaine hydrochloride were selected as quantitative peaks.The established 1H-qNMR method was applied for the quantification of 168 seized samples,the content of heroin and cocaine were basically consistent with the results of High-performance liquid chromatography.This method is simple,fast,accurate,does not require standard samples,and shows good tolerance and high reproducibility.It can provide new ideas for the quantification and profiling analysis of seized drug samples.关键词
1H定量核磁共振波谱法/海洛因/可卡因/定量分析/掺杂物Key words
1H-quantitative nuclear magnetic resonance spectroscopy(1H-qNMR)/heroin/cocaine/quantitative analysis/adulterants分类
政治法律引用本文复制引用
宋春辉,贾薇,刘翠梅,花镇东..1H-qNMR用于海洛因、可卡因及常见掺杂物定量分析的方法研究[J].刑事技术,2025,50(3):243-251,9.基金项目
国家重点研发计划项目(2022YFC3300902) （2022YFC3300902）
公安部科技计划项目(2021JC23) （2021JC23）
