新发传染病电子杂志2025，Vol.10Issue(2)：7-13,7.DOI:10.19871/j.cnki.xfcrbzz.2025.02.002
人感染H10N3禽流感的影像学表现与病理机制分析——附2例病例报道
Imaging manifestations and pathological mechanism analysis of human infection with H10N3 avian influenza virus pneumonia:a report of two cases
摘要
Abstract
Human infection with H10N3 avian virus pneumonia is a rare respiratory infectious disease caused by H10N3 subtype avian influenza virus.While demonstrating low pathogenicity in avian populations,cross-species infection in humans may manifest as severe viral pneumonia,potentially progressing to life-threatening complications including acute respiratory distress syndrome(ARDS)and multi-organ failure.The first confirmed case of human infection with H10N3 avian influenza virus iwas reported in Jiangsu Province in 2021,followed by three more cases in China.This study conducted comprehensive analyses of imaging manifestations and underlying pathological mechanisms based on clinical data from confirmed cases in Yunnan and Guangxi regions,aiming to elucidate the characteristic imaging features of human H10N3 avian influenza virus pneumonia.The investigation revealed a triphasic temporal pattern in radiological evolution,demonstrating distinct stage-specific radiological characteristics that can be categorized into three progressive phases:① Early stage(day 1-7 of disease progression):ground glass density with patchy consolidation appeared in both lungs.②Progression period(day 8-20 of disease progression):enlargement and fusion of consolidation areas,thickening of interlobular septa,and air bronchogram sign.③ Recovery period(day≥21 of disease progression):tractional bronchiectasis and reticular fibrosis lesions.his study provides certain guiding significance for people in understanding the imaging manifestations,clinical diagnosis,differential diagnosis,efficacy evaluation,and prognosis judgment of human infection with H10N3 avian influenza virus pneumonia.关键词
人感染H10N3禽流感/影像学特征/病理机制/影像学随访/肺纤维化Key words
H10N3 avian influenza/Imaging characteristics/Pathological mechanisms/Imaging follow-up/Pulmonary fibrosis分类
临床医学引用本文复制引用
李敏媛,单秋兰,张乐,覃春乐,李翔,卢亦波..人感染H10N3禽流感的影像学表现与病理机制分析——附2例病例报道[J].新发传染病电子杂志,2025,10(2):7-13,7.基金项目
1.广西重点研发计划(桂科AB25069097) （桂科AB25069097）
2.南宁市兴宁区发展改革和科学技术局重点研发计划(2022A11) （2022A11）
