针刺研究2025，Vol.50Issue(6)：714-720,7.DOI:10.13702/j.1000-0607.20240237
α-突触核蛋白在针刺治疗帕金森病中的作用研究进展
Research progress on the effect of α-synuclein in acupuncture treatment for Parkinson's disease
摘要
Abstract
Parkinson's disease(PD)is a chronic progressive neurological degenerative disease caused by the degeneration of dopaminergic neurons in the substantia nigra.α-synuclein(α-Syn)misfolding and aggregation is the crucial pathogenesis of PD,and is closely related to the other pathogenesis,such as brain-gut axis dysfunction,mitochondrial dysfunction,oxidative stress,neuroinflammation,iron and lipid metabolic disorders,and autophagy lysosomal dysfunction.Acupuncture plays a neuroprotective role by attenuating neuroinflammation,regulating brain-gut axis,repairing ubiquitin-proteasome system and autophagy lysosomal system,and modulating signaling pathways,so as to inhibit α-Syn abnormal folding and aggregation.This article reviews the effect of α-Syn in the pathogenesis of PD and acupuncture treatment,so as to provide the valuable guidance for clinical treatment.关键词
帕金森病/α-突触核蛋白/针刺/研究进展Key words
Parkinson's disease/α-synuclein/Acupuncture/Research progress引用本文复制引用
申一韦,王顺,白妍,王玉琳,何聪,张宇,刘正楠..α-突触核蛋白在针刺治疗帕金森病中的作用研究进展[J].针刺研究,2025,50(6):714-720,7.基金项目
黑龙江省省属科研院所科研业务费项目(No.CZKYF2020B003) （No.CZKYF2020B003）
